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- W2092143315 abstract "alpha-Conotoxins that target the neuronal nicotinic acetylcholine receptor have a range of potential therapeutic applications and are valuable probes for examining receptor subtype selectivity. The three-dimensional structures of about half of the known neuronal specific alpha-conotoxins have now been determined and have a consensus fold containing a helical region braced by two conserved disulfide bonds. These disulfide bonds define the two-loop framework characteristic for alpha-conotoxins, CCX(m)CX(n)C, where loop 1 comprises four residues (m = 4) and loop 2 between three and seven residues (n = 3, 6 or 7). Structural studies, particularly using NMR spectroscopy have provided an insight into the role and spatial location of residues implicated in receptor binding and biological activity." @default.
- W2092143315 created "2016-06-24" @default.
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- W2092143315 date "2004-06-01" @default.
- W2092143315 modified "2023-10-14" @default.
- W2092143315 title "Structure-activity relationships of alpha-conotoxins targeting neuronal nicotinic acetylcholine receptors" @default.
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- W2092143315 doi "https://doi.org/10.1111/j.1432-1033.2004.04148.x" @default.
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