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• W2092144788 abstract "As our society is growing older, the consequences of aging have begun to gain particular attention. Improvement of quality of life at old age and prevention of age-associated diseases have become the main focus of the aging research. The process of aging in humans is complex and underlies multiple influences, with the probable involvement of heritable and various environmental factors. In particular, hormones are decisively involved in the generation of aging. Over time, important circulating hormones decline due to a reduced secretion of the pituitary, the adrenal glands and the gonads or due to an intercurrent disease. Among them, serum levels of growth factors and sexual steroids show significant aging-associated changes. Within the scope of the Explorative Project ‘Genetic aetiology of human longevity’ supported by the German National Genome Research Network 2 (NGFN-2) an in vitro model of human hormonal aging has been developed. Human SZ95 sebocytes were maintained under a hormone-substituted environment consisting of growth factors and sexual steroids in concentrations corresponding to those circulating in 20- and in 60-year-old women. Eight hundred and ninety-nine genes showed a differential expression in SZ95 sebocytes maintained under the 20- and 60-year-old hormone mixture, respectively. Among them genes were regulated which are involved in biological processes which are all hallmarks of aging. The most significantly altered signaling pathway identified was that of the transforming growth factor-β (TGF-β). A disturbed function of this cascade has been associated with tumorigenesis, i.e. in pancreatic, prostate, intestine, breast, and uterine cancer. Interestingly, genes expressed in signaling pathways operative in age-associated diseases such as Huntington’s disease (HD), dentatorubral-pallidoluysian atrophy (DRPLA), and amyotrophic lateral sclerosis (ALS) were also identified. These data demonstrate that skin and its appendages may represent an adequate model for aging research. Hormones interact in a complex fashion, and aging may be partly attributed to the changes in their circulating blood levels. Furthermore, a disturbed hormone status may partially act towards the manifestation of neurodegenerative diseases. Thus, these results could be a basis for an integrated and interdisciplinary approach to the analysis of the aging process." @default.
• W2092144788 created "2016-06-24" @default.
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• W2092144788 date "2007-09-01" @default.
• W2092144788 modified "2023-09-30" @default.
• W2092144788 title "The skin as a mirror of the aging process in the human organism – State of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)" @default.
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• W2092144788 cites W1514533495 @default.
• W2092144788 cites W1593442063 @default.
• W2092144788 cites W17288121 @default.
• W2092144788 cites W1848156198 @default.
• W2092144788 cites W1964005327 @default.
• W2092144788 cites W1967712621 @default.
• W2092144788 cites W1969619888 @default.
• W2092144788 cites W1972734996 @default.
• W2092144788 cites W1979201224 @default.
• W2092144788 cites W1988750135 @default.
• W2092144788 cites W1993190627 @default.
• W2092144788 cites W1994972521 @default.
• W2092144788 cites W1995994732 @default.
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• W2092144788 cites W2007350878 @default.
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• W2092144788 cites W2013663859 @default.
• W2092144788 cites W2013926482 @default.
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• W2092144788 cites W2031661874 @default.
• W2092144788 cites W2031986873 @default.
• W2092144788 cites W2039810258 @default.
• W2092144788 cites W2041873776 @default.
• W2092144788 cites W2049954179 @default.
• W2092144788 cites W2053161927 @default.
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• W2092144788 cites W2054754198 @default.
• W2092144788 cites W2058350561 @default.
• W2092144788 cites W2062126815 @default.
• W2092144788 cites W2078313527 @default.
• W2092144788 cites W2081975982 @default.
• W2092144788 cites W2084966393 @default.
• W2092144788 cites W2087540265 @default.
• W2092144788 cites W2092850028 @default.
• W2092144788 cites W2093514870 @default.
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• W2092144788 cites W2108232839 @default.
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• W2092144788 cites W2110977684 @default.
• W2092144788 cites W2119526069 @default.
• W2092144788 cites W2127193566 @default.
• W2092144788 cites W2133469432 @default.
• W2092144788 cites W2151982752 @default.
• W2092144788 cites W2154926269 @default.
• W2092144788 cites W2164733896 @default.
• W2092144788 cites W2188235060 @default.
• W2092144788 cites W2331609610 @default.
• W2092144788 cites W2386107675 @default.
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• W2092144788 doi "https://doi.org/10.1016/j.exger.2007.07.002" @default.
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• W2092144788 hasPublicationYear "2007" @default.
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