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- W2092145121 abstract "Abstract Male rats 3–4 months old were fed isocaloric diets containing either 6.7 or 22% casein and were treated with 1 mg./day of growth hormone (STH) for 20–28 days. When the dietary protein level was low the incorporation in vitro of sodium acetate-2-C 14 into liver cholesterol was increased. Long-term administration of STH led to a depression in the in vivo and in vitro incorporation of acetate, but this was significant only when the dietary protein was low. The in vivo incorporation of mevalonic acid-2-C 14 into liver cholesterol was increased when the diet used was low in protein, but the administration of STH had no significant depressant effect on this elevation. Observations were made on the effects of dietary protein level and STH on body weight, liver weight, liver composition, serum cholesterol level, and incorporation of sodium acetate-2-C 14 into liver protein, fatty acids, and respiratory carbon dioxide. Results were interpreted to indicate that STH mediates its effects on acetate utilization for cholesterol synthesis via the retention of dietary protein." @default.
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- W2092145121 date "1961-01-01" @default.
- W2092145121 modified "2023-09-27" @default.
- W2092145121 title "The effect of growth hormone administration and dietary protein on the incorporation of sodium acetate-2-C14 and mevalonic acid-2-C14 into liver cholesterol" @default.
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- W2092145121 doi "https://doi.org/10.1016/0003-9861(61)90221-1" @default.
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