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- W2092145792 abstract "The effect of colecystokinin (CCK-8) on the release of ACh from the cerebral cortex was studied in urethane-anaesthetized rats with the cortical cup technique. The increase in output of ACh brought about by the administration of CCK-8 1.5μgkg (i.p.) was prevented by pretreatment with haloperidol (1 mgkg i.p.) and by lesions of the nucleus basalis magnocellularis and substantia nigra but it was reduced only slightly by bilateral vagotomy. Conversely, none of the treatments abolished the decrease in output of ACh brought about by CCK-8 at a dose of 10 μgkg (i.p.). Local injection of CCK-8 into the nucleus basalis had no effect. Therefore, CCK-8 appears to increase cortical cholinergic activity by indirectly stimulating the cholinergic neurones of the nucleus basalis through dopaminergic neurones." @default.
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- W2092145792 date "1987-08-01" @default.
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- W2092145792 title "An analysis of cholecystokinin-induced increase in acetylcholine output from cerebral cortex of the rat" @default.
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- W2092145792 doi "https://doi.org/10.1016/0028-3908(87)90270-x" @default.
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