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- W2092146517 abstract "Acetyl-3,5-Br-82-dibromosalicylic acid (dibromoaspirin) was synthesized by radiobromination of salicylic acid to yield 3,5-dibromosalicylic acid, followed by acetylation of this intermediate. Biodistribution studies in mice with and without a neuroblastoma showed that the tumor/blood radioactivity ratio was low (0.3 at one hour). Thin layer chromatography of urine indicated that only 20 to 30% of the radioactivity corresponded to dibromoaspirin. Studies of rabbits with inflammatory lesions showed that the inflammatory/normal tissue uptake ratio was 1.0 to 1.9. The RBC/plasma ratio was less than 0.5. Low uptake of radioactivity was likely due to rapid dehalogenation in vivo." @default.
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- W2092146517 date "1981-09-01" @default.
- W2092146517 modified "2023-09-23" @default.
- W2092146517 title "Synthesis and biodistribution of acetyl-3,5-br-82-dibromosalicylic acid" @default.
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