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• W2092151305 startingPage "2742" @default.
• W2092151305 abstract "Little is known about the native properties of unitary cardiac L-type calcium currents (iCa) measured with physiological calcium (Ca) ion concentration, and their role in excitation-contraction (E-C) coupling. Our goal was to chart the concentration-dependence of unitary conductance (γ) to physiological Ca concentration and compare it to barium ion (Ba) conductance in the absence of agonists. In isolated, K-depolarized rat myocytes, iCa amplitudes were measured using cell-attached patches with 2 to 70 mM Ca or 2 to 105 mM Ba in the pipette. At 0 mV, 2 mM of Ca produced 0.12 pA, and 2 mM of Ba produced 0.19 pA unitary currents. Unitary conductance was described by a Langmuir isotherm relationship with a maximum γCa of 5.3 ± 0.2 pS (n = 15), and γBa of 15 ± 1 pS (n = 27). The concentration producing half-maximal γ, Kd(γ), was not different between Ca (1.7 ± 0.3 mM) and Ba (1.9 ± 0.4 mM). We found that quasi-physiological concentrations of Ca produced currents that were as easily resolvable as those obtained with the traditionally used higher concentrations. This study leads to future work on the molecular basis of E-C coupling with a physiological concentration of Ca ions permeating the Ca channel." @default.
• W2092151305 created "2016-06-24" @default.
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• W2092151305 date "2001-06-01" @default.
• W2092151305 modified "2023-10-16" @default.
• W2092151305 title "Ion Concentration-Dependence of Rat Cardiac Unitary L-Type Calcium Channel Conductance" @default.
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• W2092151305 doi "https://doi.org/10.1016/s0006-3495(01)76242-x" @default.
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