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• W2092152178 startingPage "1922" @default.
• W2092152178 abstract "For effective bioactive small molecule discovery and development into new therapeutic drug, a systematic screening and target protein identification is required. Different from the conventional screening system, herein phenotypic screening in combination with multi-omics-based target identification and validation (MOTIV) is introduced. First, phenotypic screening provides visual effect of bioactive small molecules in the cell or organism level. It is important to know the effect on the cell or organism level since small molecules affect not only a single target but the entire cellular mechanism within a cell or organism. Secondly, MOTIV provides systemic approach to discover the target protein of bioactive small molecule. With the chemical genomics and proteomics approach of target identification methods, various target protein candidates are identified. Then network analysis and validations of these candidates result in identifying the biologically relevant target protein and cellular mechanism. Overall, the combination of phenotypic screening and MOTIV will provide an effective approach to discover new bioactive small molecules and their target protein and mechanism identification." @default.
• W2092152178 created "2016-06-24" @default.
• W2092152178 creator A5027949797 @default.
• W2092152178 creator A5067684286 @default.
• W2092152178 date "2012-03-01" @default.
• W2092152178 modified "2023-10-14" @default.
• W2092152178 title "Identification and validation of bioactive small molecule target through phenotypic screening" @default.
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• W2092152178 doi "https://doi.org/10.1016/j.bmc.2011.11.021" @default.
• W2092152178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22153994" @default.
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