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- W2092153968 abstract "A GnRH-expressing neuronal cell line (NLT) was used to determine whether insulin-like growth factor I (IGF-I) regulates GnRH gene expression. A receptor-binding assay demonstrated the expression of IGF-I receptors on NLT cells. Activation of IGF-I receptors induced the Ras/Raf-1/mitogen-activated protein kinase pathway and increased c-fos expression. NLT cells treated with IGF-I underwent cell proliferation and exhibited a growth-independent increase in mouse GnRH mRNA expression. In cells transfected with DNA constructs containing the human GnRH promoter, which includes a consensus AP-1 binding site fused to the luciferase reporter gene, a significant increase in reporter activities was induced by IGF-I, whereas mutation of this AP-1 site significantly reduced IGF-I-induced promoter activation. These results demonstrate that IGF-I serves as an important signal in the regulation of both human and rodent GnRH gene expression." @default.
- W2092153968 created "2016-06-24" @default.
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- W2092153968 date "1997-07-01" @default.
- W2092153968 modified "2023-09-26" @default.
- W2092153968 title "Regulation of Gonadotropin-Releasing Hormone (GnRH) Gene Expression by Insulin-Like Growth Factor I in a Cultured GnRH-Expressing Neuronal Cell Line" @default.
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- W2092153968 doi "https://doi.org/10.1210/mend.11.8.9956" @default.
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