Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092156928> ?p ?o ?g. }
- W2092156928 endingPage "221" @default.
- W2092156928 startingPage "208" @default.
- W2092156928 abstract "Voltage-gated sodium channels underlie action potential generation in excitable tissue. To establish the evolutionary mechanisms that shaped the vertebrate sodium channel α-subunit (SCNA) gene family and their encoded Nav1 proteins, we identified all SCNA genes in several teleost species. Molecular cloning revealed that teleosts have eight SCNA genes, compared to ten in another vertebrate lineage, mammals. Prior phylogenetic analyses have indicated that the genomes of both teleosts and tetrapods contain four monophyletic groups of SCNA genes, and that tandem duplications expanded the number of genes in two of the four mammalian groups. However, the number of genes in each group varies between teleosts and tetrapods, suggesting different evolutionary histories in the two vertebrate lineages. Our findings from phylogenetic analysis and chromosomal mapping of Danio rerio genes indicate that tandem duplications are an unlikely mechanism for generation of the extant teleost SCNA genes. Instead, analyses of other closely mapped genes in D. rerio as well as of SCNA genes from several teleost species all support the hypothesis that a whole-genome duplication was involved in expansion of the SCNA gene family in teleosts. Interestingly, despite their different evolutionary histories, mRNA analyses demonstrated a conservation of expression patterns for SCNA orthologues in teleosts and tetrapods, suggesting functional conservation." @default.
- W2092156928 created "2016-06-24" @default.
- W2092156928 creator A5031299935 @default.
- W2092156928 creator A5032633467 @default.
- W2092156928 creator A5060946050 @default.
- W2092156928 creator A5066039651 @default.
- W2092156928 creator A5067500646 @default.
- W2092156928 creator A5087215389 @default.
- W2092156928 date "2006-07-07" @default.
- W2092156928 modified "2023-10-01" @default.
- W2092156928 title "Gene Duplications and Evolution of Vertebrate Voltage-Gated Sodium Channels" @default.
- W2092156928 cites W1549160512 @default.
- W2092156928 cites W1606667854 @default.
- W2092156928 cites W1665224264 @default.
- W2092156928 cites W1849633811 @default.
- W2092156928 cites W1943370252 @default.
- W2092156928 cites W1965856458 @default.
- W2092156928 cites W1977070082 @default.
- W2092156928 cites W1980177621 @default.
- W2092156928 cites W1981324262 @default.
- W2092156928 cites W1985110561 @default.
- W2092156928 cites W1989034440 @default.
- W2092156928 cites W1991798507 @default.
- W2092156928 cites W1998314398 @default.
- W2092156928 cites W1999145879 @default.
- W2092156928 cites W1999672224 @default.
- W2092156928 cites W2000702493 @default.
- W2092156928 cites W2003918316 @default.
- W2092156928 cites W2007640952 @default.
- W2092156928 cites W2007944782 @default.
- W2092156928 cites W2018057404 @default.
- W2092156928 cites W2021987019 @default.
- W2092156928 cites W2030180991 @default.
- W2092156928 cites W2049896656 @default.
- W2092156928 cites W2050538166 @default.
- W2092156928 cites W2054785832 @default.
- W2092156928 cites W2058327557 @default.
- W2092156928 cites W2065857917 @default.
- W2092156928 cites W2068738439 @default.
- W2092156928 cites W2080882866 @default.
- W2092156928 cites W2082822369 @default.
- W2092156928 cites W2084363118 @default.
- W2092156928 cites W2088237761 @default.
- W2092156928 cites W2091746433 @default.
- W2092156928 cites W2103056085 @default.
- W2092156928 cites W2105710687 @default.
- W2092156928 cites W2106882534 @default.
- W2092156928 cites W2114457659 @default.
- W2092156928 cites W2118961532 @default.
- W2092156928 cites W2119237189 @default.
- W2092156928 cites W2120960764 @default.
- W2092156928 cites W2127121086 @default.
- W2092156928 cites W2128983351 @default.
- W2092156928 cites W2134353614 @default.
- W2092156928 cites W2137845412 @default.
- W2092156928 cites W2142345378 @default.
- W2092156928 cites W2144389195 @default.
- W2092156928 cites W2144955265 @default.
- W2092156928 cites W2155365016 @default.
- W2092156928 cites W2155825778 @default.
- W2092156928 cites W2159332152 @default.
- W2092156928 cites W2161444534 @default.
- W2092156928 cites W2168107590 @default.
- W2092156928 cites W4229487902 @default.
- W2092156928 doi "https://doi.org/10.1007/s00239-005-0287-9" @default.
- W2092156928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16830092" @default.
- W2092156928 hasPublicationYear "2006" @default.
- W2092156928 type Work @default.
- W2092156928 sameAs 2092156928 @default.
- W2092156928 citedByCount "79" @default.
- W2092156928 countsByYear W20921569282012 @default.
- W2092156928 countsByYear W20921569282013 @default.
- W2092156928 countsByYear W20921569282014 @default.
- W2092156928 countsByYear W20921569282015 @default.
- W2092156928 countsByYear W20921569282016 @default.
- W2092156928 countsByYear W20921569282017 @default.
- W2092156928 countsByYear W20921569282018 @default.
- W2092156928 countsByYear W20921569282019 @default.
- W2092156928 countsByYear W20921569282020 @default.
- W2092156928 countsByYear W20921569282021 @default.
- W2092156928 countsByYear W20921569282022 @default.
- W2092156928 countsByYear W20921569282023 @default.
- W2092156928 crossrefType "journal-article" @default.
- W2092156928 hasAuthorship W2092156928A5031299935 @default.
- W2092156928 hasAuthorship W2092156928A5032633467 @default.
- W2092156928 hasAuthorship W2092156928A5060946050 @default.
- W2092156928 hasAuthorship W2092156928A5066039651 @default.
- W2092156928 hasAuthorship W2092156928A5067500646 @default.
- W2092156928 hasAuthorship W2092156928A5087215389 @default.
- W2092156928 hasBestOaLocation W20921569282 @default.
- W2092156928 hasConcept C104317684 @default.
- W2092156928 hasConcept C12326286 @default.
- W2092156928 hasConcept C141036 @default.
- W2092156928 hasConcept C141231307 @default.
- W2092156928 hasConcept C156446351 @default.
- W2092156928 hasConcept C166393388 @default.
- W2092156928 hasConcept C167625842 @default.
- W2092156928 hasConcept C193252679 @default.