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• W2092157420 abstract "Placental insufficiency results in intrauterine growth restriction (IUGR), impaired fetal insulin secretion and less fetal pancreatic β-cell mass, partly due to lower β-cell proliferation rates. Insulin-like growth factors (IGFs) and fibroblast growth factors (FGFs) regulate fetal β-cell proliferation and pancreas development, along with transcription factors, such as pancreatic and duodenal homeobox 1 (PDX-1). We determined expression levels for these growth factors, their receptors and IGF binding proteins in ovine fetal pancreas and isolated islets. In the IUGR pancreas, relative mRNA expression levels of IGF-I, PDX-1, FGF7 and FGFR2IIIb were 64% ( P < 0.01), 76% ( P < 0.05), 76% ( P < 0.05) and 52% ( P < 0.01) lower, respectively, compared with control fetuses. Conversely, insulin-like growth factor binding protein 2 (IGFBP-2) mRNA and protein concentrations were 2.25- and 1.2-fold greater ( P < 0.05) in the IUGR pancreas compared with controls. In isolated islets from IUGR fetuses, IGF-II and IGFBP-2 mRNA concentrations were 1.5- and 3.7-fold greater ( P < 0.05), and insulin mRNA was 56% less ( P < 0.05) than control islets. The growth factor expression profiles for IGF and FGF signaling pathways indicate that declines in β-cell mass are due to decreased growth factor signals for both pancreatic progenitor epithelial cell and mature β-cell replication." @default.
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• W2092157420 date "2012-05-01" @default.
• W2092157420 modified "2023-09-23" @default.
• W2092157420 title "Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas" @default.
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• W2092157420 doi "https://doi.org/10.1258/ebm.2012.011375" @default.
• W2092157420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3404611" @default.
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