Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092158576> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2092158576 endingPage "1036" @default.
- W2092158576 startingPage "1030" @default.
- W2092158576 abstract "Summary: Samples of plasma or serum from 53 cystic fibrosis (CF) patients, 90 relatives of CF patients, and 159 controls have been incubated with porcine or bovine 125I-trypsin, electrophoresed on polyacrylamide gel, and autoradiographed. In these individuals, the main binding protein for 125I-trypsin has been shown to be α2-macroglobulin (α2M). Using this method of analysis, no difference in electrophoretic migration of 125I-trypsin-α2M complexes has been observed between CF and control individuals. However, trypsin binding to IgG has been observed in 80% of CF patients, 30% of their mothers, 3% of controls, and in two patients affected with pancreatitis. These trypsin binding immunoglobulins are called Tblg, and specifically, TblgG when referring to the G class. Experimental evidence indicates that binding of trypsin to IgG occurs through the Fab portion of the molecule. TblgG must be antibodies most probably induced by the exogenous trypsin ingested daily by most CF patients (and by patients affected with chronic pancreatitis). Antibodies against porcine pancreatic elastase have been observed using the same analysis, but not as frequently as Tblg. Speculation: Antibodies against trypsin are known to have an inhibitory capacity on its enzymatic activity: is Tblg responsible, at least in part, for the decrease in arginine esterase activity observed by some authors in plasma of CF patients and of some heterozygotes? The presence of TblgG in CF patients raises again the interesting question of an autoimmune process in CF, directed not only against structural pancreatic proteins but also against human pancreatic enzymes." @default.
- W2092158576 created "2016-06-24" @default.
- W2092158576 creator A5011953010 @default.
- W2092158576 creator A5048416060 @default.
- W2092158576 creator A5051357358 @default.
- W2092158576 creator A5055342371 @default.
- W2092158576 creator A5071291395 @default.
- W2092158576 date "1979-09-01" @default.
- W2092158576 modified "2023-09-27" @default.
- W2092158576 title "Binding of 125I-Labeled Proteinases to Plasma Proteins in Cystic Fibrosis" @default.
- W2092158576 doi "https://doi.org/10.1203/00006450-197909000-00017" @default.
- W2092158576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/92005" @default.
- W2092158576 hasPublicationYear "1979" @default.
- W2092158576 type Work @default.
- W2092158576 sameAs 2092158576 @default.
- W2092158576 citedByCount "6" @default.
- W2092158576 crossrefType "journal-article" @default.
- W2092158576 hasAuthorship W2092158576A5011953010 @default.
- W2092158576 hasAuthorship W2092158576A5048416060 @default.
- W2092158576 hasAuthorship W2092158576A5051357358 @default.
- W2092158576 hasAuthorship W2092158576A5055342371 @default.
- W2092158576 hasAuthorship W2092158576A5071291395 @default.
- W2092158576 hasBestOaLocation W20921585761 @default.
- W2092158576 hasConcept C126322002 @default.
- W2092158576 hasConcept C134018914 @default.
- W2092158576 hasConcept C153911025 @default.
- W2092158576 hasConcept C159654299 @default.
- W2092158576 hasConcept C181199279 @default.
- W2092158576 hasConcept C185592680 @default.
- W2092158576 hasConcept C203014093 @default.
- W2092158576 hasConcept C2775967933 @default.
- W2092158576 hasConcept C2776938444 @default.
- W2092158576 hasConcept C2780340462 @default.
- W2092158576 hasConcept C2781044401 @default.
- W2092158576 hasConcept C2781054842 @default.
- W2092158576 hasConcept C55493867 @default.
- W2092158576 hasConcept C71924100 @default.
- W2092158576 hasConcept C86803240 @default.
- W2092158576 hasConceptScore W2092158576C126322002 @default.
- W2092158576 hasConceptScore W2092158576C134018914 @default.
- W2092158576 hasConceptScore W2092158576C153911025 @default.
- W2092158576 hasConceptScore W2092158576C159654299 @default.
- W2092158576 hasConceptScore W2092158576C181199279 @default.
- W2092158576 hasConceptScore W2092158576C185592680 @default.
- W2092158576 hasConceptScore W2092158576C203014093 @default.
- W2092158576 hasConceptScore W2092158576C2775967933 @default.
- W2092158576 hasConceptScore W2092158576C2776938444 @default.
- W2092158576 hasConceptScore W2092158576C2780340462 @default.
- W2092158576 hasConceptScore W2092158576C2781044401 @default.
- W2092158576 hasConceptScore W2092158576C2781054842 @default.
- W2092158576 hasConceptScore W2092158576C55493867 @default.
- W2092158576 hasConceptScore W2092158576C71924100 @default.
- W2092158576 hasConceptScore W2092158576C86803240 @default.
- W2092158576 hasIssue "9" @default.
- W2092158576 hasLocation W20921585761 @default.
- W2092158576 hasLocation W20921585762 @default.
- W2092158576 hasOpenAccess W2092158576 @default.
- W2092158576 hasPrimaryLocation W20921585761 @default.
- W2092158576 hasRelatedWork W1569146252 @default.
- W2092158576 hasRelatedWork W1573584092 @default.
- W2092158576 hasRelatedWork W1813930860 @default.
- W2092158576 hasRelatedWork W2044546508 @default.
- W2092158576 hasRelatedWork W2065797285 @default.
- W2092158576 hasRelatedWork W2078595220 @default.
- W2092158576 hasRelatedWork W2287480131 @default.
- W2092158576 hasRelatedWork W2413277462 @default.
- W2092158576 hasRelatedWork W2474933031 @default.
- W2092158576 hasRelatedWork W31665950 @default.
- W2092158576 hasVolume "13" @default.
- W2092158576 isParatext "false" @default.
- W2092158576 isRetracted "false" @default.
- W2092158576 magId "2092158576" @default.
- W2092158576 workType "article" @default.