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• W2092161213 startingPage "1539" @default.
• W2092161213 abstract "To study the role of brain responses to thermal stimulation in outcome prediction of patients in either vegetative or minimally conscious states. We performed a prospective study with 22 patients and used functional magnetic resonance imaging (fMRI) and EEG reactivity (EEG-R) tests in conjunction with thermal stimulation. We conducted thermal stimulation on patients by stimulating either their feet (fMRI) or hands (EEEG-R) with warm water (42 ± 2 °C). Each patient received a 1-year follow-up. Among the 22 patients, 1 was lost to follow- up, 10 had improved outcomes, and the remaining 11 patients showed no improvement. Thermal stimulation induced three different fMRI brain activation patterns: (1) high-order activation in 4 patients, (2) primary activation in 6 patients, and (3) no activation in 11 patients. Eight of the 10 patients with either high-order or primary activation had an improved outcome. Contrastingly, only 2 of the 11 patients with no activation pattern showed improvement. EEG-R was elicited in 11 patients and 9 of them showed improved outcomes. However, among the 10 patients with no EEG-R, 9 patients did not improve. Using fMRI and EEG to measure brain responses to thermal stimulation is capable of predicting patient outcomes with a high degree of predictive accuracy. Thermal stimulation can be used as an objective and quantifiable somatosensory stimulation mode for clinical EEG-R and fMRI tests." @default.
• W2092161213 created "2016-06-24" @default.
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• W2092161213 date "2015-08-01" @default.
• W2092161213 modified "2023-10-01" @default.
• W2092161213 title "Brain response to thermal stimulation predicts outcome of patients with chronic disorders of consciousness" @default.
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• W2092161213 doi "https://doi.org/10.1016/j.clinph.2014.10.148" @default.
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