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- W2092164049 abstract "Excitatory neuronal activity produces beneficial influences on neuronal survival under several circumstances. We show that cultivation of rat midbrain slices in the presence of elevated extracellular Mg2+ resulted in a marked decrease in the number of dopaminergic neurons. The effect was prominent when Mg2+ was added to the medium during the first week of cultivation. Chronic treatment with antagonists of N-methyl-d-aspartate receptors such as 2-amino-5-phosphonovaleric acid, MK-801 and ifenprodil also resulted in a marked loss of dopaminergic neurons, whereas nicotinic receptor antagonists showed no effect. The effect of MK-801 was abolished by chronic depolarization by elevated extracellular K+, or by application of forskolin or dibutyryl cyclic AMP. Thus, tonic activation of N-methyl-d-aspartate receptors driven by neuronal activity may play an important role in the maintenance of dopaminergic neurons." @default.
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- W2092164049 date "2003-05-01" @default.
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- W2092164049 title "N-Methyl-d-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures" @default.
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- W2092164049 doi "https://doi.org/10.1016/s0304-3940(03)00176-9" @default.
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