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- W2092164518 endingPage "6785" @default.
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- W2092164518 abstract "Abstract The acquired von Willebrand syndrome (AVWS) is a bleeding disorder that is frequently unrecognized or is misdiagnosed as von Willebrand disease. AVWS is characterized by structural or functional defects of von Willebrand factor (VWF) that are secondary to autoimmune, lymphoproliferative or myeloproliferative, malignant, cardiovascular, or other disorders. VWF abnormalities in these disorders can result from (1) antibody-mediated clearance or functional interference, (2) adsorption to surfaces of transformed cells or platelets, or (3) increased shear stress and subsequent proteolysis. Diagnosis can be challenging as no single test is usually sufficient to prove or exclude AVWS. Furthermore, there are no evidence-based guidelines for management. Treatments of the underlying medical condition, including chemo/radiotherapy, surgery, or immunosuppressants can result in remission of AVWS, but is not always feasible and successful. Because of the heterogeneous mechanisms of AVWS, more than one therapeutic approach is often required to treat acute bleeds and for prophylaxis during invasive procedures; the treatment options include, but are not limited to, desmopressin, VWF-containing concentrates, intravenous immunoglobulin, plasmapheresis or recombinant factor VIIa. Here, we review the management of AVWS with an overview on the currently available evidence and additional considerations for typical treatment situations." @default.
- W2092164518 created "2016-06-24" @default.
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- W2092164518 date "2011-06-23" @default.
- W2092164518 modified "2023-10-07" @default.
- W2092164518 title "How I treat the acquired von Willebrand syndrome" @default.
- W2092164518 cites W122768941 @default.
- W2092164518 cites W166660488 @default.
- W2092164518 cites W167633943 @default.
- W2092164518 cites W1785732432 @default.
- W2092164518 cites W1831354387 @default.
- W2092164518 cites W1877699882 @default.
- W2092164518 cites W1965821703 @default.
- W2092164518 cites W1969059748 @default.
- W2092164518 cites W1973099470 @default.
- W2092164518 cites W1973897127 @default.
- W2092164518 cites W1978771401 @default.
- W2092164518 cites W1979999370 @default.
- W2092164518 cites W1988063892 @default.
- W2092164518 cites W1993175688 @default.
- W2092164518 cites W1997135901 @default.
- W2092164518 cites W1999680744 @default.
- W2092164518 cites W2004777016 @default.
- W2092164518 cites W2006432872 @default.
- W2092164518 cites W2012640192 @default.
- W2092164518 cites W2013735549 @default.
- W2092164518 cites W2013845341 @default.
- W2092164518 cites W2018457377 @default.
- W2092164518 cites W2021185226 @default.
- W2092164518 cites W2025282390 @default.
- W2092164518 cites W2036927323 @default.
- W2092164518 cites W2037197317 @default.
- W2092164518 cites W2041092771 @default.
- W2092164518 cites W2042038589 @default.
- W2092164518 cites W2049539516 @default.
- W2092164518 cites W2059004434 @default.
- W2092164518 cites W2062692004 @default.
- W2092164518 cites W2063381949 @default.
- W2092164518 cites W2064690570 @default.
- W2092164518 cites W2065124959 @default.
- W2092164518 cites W2066198380 @default.
- W2092164518 cites W2068476516 @default.
- W2092164518 cites W206963309 @default.
- W2092164518 cites W2073008793 @default.
- W2092164518 cites W2081737706 @default.
- W2092164518 cites W2087753467 @default.
- W2092164518 cites W2092322834 @default.
- W2092164518 cites W2105306249 @default.
- W2092164518 cites W2106552212 @default.
- W2092164518 cites W2110660106 @default.
- W2092164518 cites W2115047246 @default.
- W2092164518 cites W2115734068 @default.
- W2092164518 cites W2124554489 @default.
- W2092164518 cites W2125959341 @default.
- W2092164518 cites W2126049488 @default.
- W2092164518 cites W2129770176 @default.
- W2092164518 cites W2130521956 @default.
- W2092164518 cites W2135442360 @default.
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- W2092164518 cites W2142404441 @default.
- W2092164518 cites W2144612836 @default.
- W2092164518 cites W2147656014 @default.
- W2092164518 cites W2149373649 @default.
- W2092164518 cites W2149779707 @default.
- W2092164518 cites W2169405856 @default.
- W2092164518 cites W2229971338 @default.
- W2092164518 cites W230817699 @default.
- W2092164518 cites W2329570522 @default.
- W2092164518 cites W2346458155 @default.
- W2092164518 cites W298319700 @default.
- W2092164518 cites W4247535347 @default.
- W2092164518 cites W4249596399 @default.
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- W2092164518 doi "https://doi.org/10.1182/blood-2010-11-297580" @default.
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