Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092164861> ?p ?o ?g. }
- W2092164861 endingPage "e15839" @default.
- W2092164861 startingPage "e15839" @default.
- W2092164861 abstract "Two distinct forms of atypical spongiform encephalopathies (H-BSE and L-BSE) have recently been identified in cattle. Transmission studies in several wild-type or transgenic mouse models showed that these forms were associated with two distinct major strains of infectious agents, which also differed from the unique strain that had been isolated from cases of classical BSE during the food-borne epizootic disease.H-BSE was monitored during three serial passages in C57BL/6 mice. On second passage, most of the inoculated mice showed molecular features of the abnormal prion protein (PrP(d)) and brain lesions similar to those observed at first passage, but clearly distinct from those of classical BSE in this mouse model. These features were similarly maintained during a third passage. However, on second passage, some of the mice exhibited distinctly different molecular and lesion characteristics, reminiscent of classical BSE in C57Bl/6 mice. These similarities were confirmed on third passage from such mice, for which the same survival time was also observed as with classical BSE adapted to C57Bl/6 mice. Lymphotropism was rarely detected in mice with H-BSE features. In contrast, PrP(d) was detectable, on third passage, in the spleens of most mice exhibiting classical BSE features, the pattern being indistinguishable from that found in C57Bl/6 mice infected with classical BSE.Our data demonstrate the emergence of a prion strain with features similar to classical BSE during serial passages of H-BSE in wild-type mice. Such findings might help to explain the origin of the classical BSE epizootic disease, which could have originated from a putatively sporadic form of BSE." @default.
- W2092164861 created "2016-06-24" @default.
- W2092164861 creator A5005769855 @default.
- W2092164861 creator A5017989541 @default.
- W2092164861 creator A5040468965 @default.
- W2092164861 creator A5061302555 @default.
- W2092164861 creator A5069031997 @default.
- W2092164861 creator A5085304984 @default.
- W2092164861 creator A5086970240 @default.
- W2092164861 date "2011-01-14" @default.
- W2092164861 modified "2023-10-03" @default.
- W2092164861 title "Emergence of Classical BSE Strain Properties during Serial Passages of H-BSE in Wild-Type Mice" @default.
- W2092164861 cites W1557724928 @default.
- W2092164861 cites W1965132458 @default.
- W2092164861 cites W1965257173 @default.
- W2092164861 cites W1976590712 @default.
- W2092164861 cites W1981387468 @default.
- W2092164861 cites W1991237179 @default.
- W2092164861 cites W1991644458 @default.
- W2092164861 cites W1995580711 @default.
- W2092164861 cites W1996346677 @default.
- W2092164861 cites W2000928261 @default.
- W2092164861 cites W2006427685 @default.
- W2092164861 cites W2011089631 @default.
- W2092164861 cites W2011574202 @default.
- W2092164861 cites W2016565903 @default.
- W2092164861 cites W2023904661 @default.
- W2092164861 cites W2027028319 @default.
- W2092164861 cites W2032102236 @default.
- W2092164861 cites W2032952473 @default.
- W2092164861 cites W2033050237 @default.
- W2092164861 cites W2049719457 @default.
- W2092164861 cites W2052107975 @default.
- W2092164861 cites W2055288092 @default.
- W2092164861 cites W2059742492 @default.
- W2092164861 cites W2064722614 @default.
- W2092164861 cites W2076328804 @default.
- W2092164861 cites W2083346670 @default.
- W2092164861 cites W2119365367 @default.
- W2092164861 cites W2119861236 @default.
- W2092164861 cites W2130432938 @default.
- W2092164861 cites W2132100305 @default.
- W2092164861 cites W2134138339 @default.
- W2092164861 cites W2138570593 @default.
- W2092164861 cites W2142073103 @default.
- W2092164861 cites W2145420465 @default.
- W2092164861 cites W2161199496 @default.
- W2092164861 cites W2167884034 @default.
- W2092164861 cites W2169074095 @default.
- W2092164861 cites W2986028677 @default.
- W2092164861 doi "https://doi.org/10.1371/journal.pone.0015839" @default.
- W2092164861 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3021503" @default.
- W2092164861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21264286" @default.
- W2092164861 hasPublicationYear "2011" @default.
- W2092164861 type Work @default.
- W2092164861 sameAs 2092164861 @default.
- W2092164861 citedByCount "60" @default.
- W2092164861 countsByYear W20921648612012 @default.
- W2092164861 countsByYear W20921648612013 @default.
- W2092164861 countsByYear W20921648612014 @default.
- W2092164861 countsByYear W20921648612015 @default.
- W2092164861 countsByYear W20921648612016 @default.
- W2092164861 countsByYear W20921648612017 @default.
- W2092164861 countsByYear W20921648612018 @default.
- W2092164861 countsByYear W20921648612019 @default.
- W2092164861 countsByYear W20921648612020 @default.
- W2092164861 countsByYear W20921648612021 @default.
- W2092164861 countsByYear W20921648612022 @default.
- W2092164861 countsByYear W20921648612023 @default.
- W2092164861 crossrefType "journal-article" @default.
- W2092164861 hasAuthorship W2092164861A5005769855 @default.
- W2092164861 hasAuthorship W2092164861A5017989541 @default.
- W2092164861 hasAuthorship W2092164861A5040468965 @default.
- W2092164861 hasAuthorship W2092164861A5061302555 @default.
- W2092164861 hasAuthorship W2092164861A5069031997 @default.
- W2092164861 hasAuthorship W2092164861A5085304984 @default.
- W2092164861 hasAuthorship W2092164861A5086970240 @default.
- W2092164861 hasBestOaLocation W20921648611 @default.
- W2092164861 hasConcept C102230213 @default.
- W2092164861 hasConcept C104317684 @default.
- W2092164861 hasConcept C127716648 @default.
- W2092164861 hasConcept C132351222 @default.
- W2092164861 hasConcept C141035611 @default.
- W2092164861 hasConcept C142724271 @default.
- W2092164861 hasConcept C143065580 @default.
- W2092164861 hasConcept C159047783 @default.
- W2092164861 hasConcept C207583985 @default.
- W2092164861 hasConcept C2522874641 @default.
- W2092164861 hasConcept C2778511750 @default.
- W2092164861 hasConcept C2779134260 @default.
- W2092164861 hasConcept C2781131914 @default.
- W2092164861 hasConcept C3019804061 @default.
- W2092164861 hasConcept C54355233 @default.
- W2092164861 hasConcept C71924100 @default.
- W2092164861 hasConcept C86803240 @default.
- W2092164861 hasConceptScore W2092164861C102230213 @default.
- W2092164861 hasConceptScore W2092164861C104317684 @default.
- W2092164861 hasConceptScore W2092164861C127716648 @default.