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• W2092166671 abstract "The pathway for selective serotonergic toxicity of 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) is poorly understood, but has been linked to hyperthermia and disturbed energy metabolism. We investigated the dose-dependency and time-course of MDMA-induced perturbations of cerebral glucose metabolism in freely moving rats using rapid sampling microdialysis (every minute) coupled to flow-injection analysis (FIA) with biosensors for glucose and lactate. Blood samples for analysis of glucose and lactate were taken at 30–45 min intervals before and after drug dosing and body temperature was monitored by telemetry. A single dose of MDMA (2–10–20 mg/kg i.v.) evoked a transient increase of interstitial glucose concentrations in striatum (139–223%) with rapid onset and of less than 2 h duration, a concomitant but more prolonged lactate increase (>187%) at the highest MDMA dose and no significant depletions of striatal serotonin. Blood glucose and lactate levels were also transiently elevated (163 and 135%) at the highest MDMA doses. The blood glucose rises were significantly related to brain glucose and brain lactate changes. The metabolic perturbations in striatum and the hyperthermic response (+1.1 °C) following systemic MDMA treatment were entirely blocked in p-chlorophenylalanine pre-treated rats, indicating that these effects are mediated by endogenous serotonin." @default.
• W2092166671 created "2016-06-24" @default.
• W2092166671 creator A5044995419 @default.
• W2092166671 creator A5078615730 @default.
• W2092166671 date "2007-07-01" @default.
• W2092166671 modified "2023-09-23" @default.
• W2092166671 title "Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) administration in awake rats" @default.
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• W2092166671 doi "https://doi.org/10.1016/j.neuint.2007.03.004" @default.
• W2092166671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17475367" @default.
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