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- W2092168013 abstract "Adult neural stem cell proliferation is dynamic and has the potential for massive self-renewal yet undergoes limited cell division in vivo. Here, we report an epigenetic mechanism regulating proliferation and self-renewal. The recruitment of the PI3K-related kinase signaling pathway and histone H2AX phosphorylation following GABA A receptor activation limits subventricular zone proliferation. As a result, NSC self-renewal and niche size is dynamic and can be directly modulated in both directions pharmacologically or by genetically targeting H2AX activation. Surprisingly, changes in proliferation have long-lasting consequences on stem cell numbers, niche size, and neuronal output. These results establish a mechanism that continuously limits proliferation and demonstrates its impact on adult neurogenesis. Such homeostatic suppression of NSC proliferation may contribute to the limited self-repair capacity of the damaged brain." @default.
- W2092168013 created "2016-06-24" @default.
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- W2092168013 date "2011-03-21" @default.
- W2092168013 modified "2023-10-16" @default.
- W2092168013 title "Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells" @default.
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- W2092168013 doi "https://doi.org/10.1073/pnas.1014993108" @default.
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