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- W2092168840 abstract "This study examines the behavioural and sleep-cycle modifications induced by four peptides (Angiotensin II: ANG II Renin; Substance P and Arginine-Vasotocin: AVT). These peptides decreased paradoxical sleep (PS) and specifically: - ANG II administered intraventricularly (IVT) at doses of 10 pg and 100 ng induced a dipsogenic effect. Paradoxical sleep was significantly decreased by 25 % with the 100 ng dose and this effect was associated with an increase in the duration of slow wave sleep (SWS). - Renin (0.01 U IVT) induced an analogous dipsogenic effect and a decrease in PS duration of 25 %, correlated with an increase in waking. - Substance P (100 ng and 1 μg IVT) did not modify behaviour. However, with the 100 ng dose PS duration was decreased by 30 % in favour of waking. - AVT (10 and 50 μg/kg intraperitoneally) induced polypnea and a dose-related decrease in PS duration (11 % for AVT at 10 μg/kg and 25 % for AVT at 50 μg/kg) together with a decrease in waking. These effects were also accompanied by an increase in PS latency (+ 125 % for AVT at 10 μg/kg and + 220 % for AVT at 50 μg/kg)." @default.
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- W2092168840 date "1982-05-01" @default.
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- W2092168840 title "Endogenous peptides and sleep in the rat: I peptides decreasing paradoxical sleep" @default.
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- W2092168840 doi "https://doi.org/10.1016/0143-4179(82)90014-2" @default.
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