FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092169550> ?p ?o ?g. }

• W2092169550 endingPage "7506" @default.
• W2092169550 startingPage "7500" @default.
• W2092169550 abstract "Abstract We recently demonstrated that caveolae, vesicular flask-shaped invaginations of the plasma membrane, represent novel therapeutic targets in multiple myeloma. In the present study, we demonstrate that vascular endothelial growth factor (VEGF) triggers Src-dependent phosphorylation of caveolin-1, which is required for p130Cas phosphorylation and multiple myeloma cell migration. Conversely, depletion of caveolin-1 by antisense methodology abrogates p130Cas phosphorylation and VEGF-triggered multiple myeloma cell migration. The proteasome inhibitor bortezomib both inhibited VEGF-triggered caveolin-1 phosphorylation and markedly decreased caveolin-1 expression. Consequently, bortezomib inhibited VEGF-induced multiple myeloma cell migration. Bortezomib also decreased VEGF secretion in the bone marrow microenvironment and inhibited VEGF-triggered tyrosine phosphorylation of caveolin-1, migration, and survival in human umbilical vascular endothelial cells. Taken together, these studies demonstrate the requirement of caveolae for VEGF-triggered multiple myeloma cell migration and identify caveolin-1 in multiple myeloma cells and human umbilical vascular endothelial cells as a molecular target of bortezomib." @default.
• W2092169550 created "2016-06-24" @default.
• W2092169550 creator A5006765393 @default.
• W2092169550 creator A5007023688 @default.
• W2092169550 creator A5024034724 @default.
• W2092169550 creator A5032464400 @default.
• W2092169550 creator A5034151974 @default.
• W2092169550 creator A5043526996 @default.
• W2092169550 creator A5055955432 @default.
• W2092169550 creator A5059167270 @default.
• W2092169550 creator A5078548012 @default.
• W2092169550 creator A5091207345 @default.
• W2092169550 date "2004-10-15" @default.
• W2092169550 modified "2023-10-02" @default.
• W2092169550 title "Caveolin-1 Is Required for Vascular Endothelial Growth Factor-Triggered Multiple Myeloma Cell Migration and Is Targeted by Bortezomib" @default.
• W2092169550 cites W1517168785 @default.
• W2092169550 cites W1557888154 @default.
• W2092169550 cites W1561311926 @default.
• W2092169550 cites W1761234319 @default.
• W2092169550 cites W1822687991 @default.
• W2092169550 cites W1860712094 @default.
• W2092169550 cites W1900495018 @default.
• W2092169550 cites W1943448711 @default.
• W2092169550 cites W1976214697 @default.
• W2092169550 cites W1980471295 @default.
• W2092169550 cites W1988431963 @default.
• W2092169550 cites W1988753461 @default.
• W2092169550 cites W1991414324 @default.
• W2092169550 cites W2008622203 @default.
• W2092169550 cites W2008924522 @default.
• W2092169550 cites W2014914858 @default.
• W2092169550 cites W2015661133 @default.
• W2092169550 cites W2021988516 @default.
• W2092169550 cites W2028020369 @default.
• W2092169550 cites W2038437697 @default.
• W2092169550 cites W2038718210 @default.
• W2092169550 cites W2040945595 @default.
• W2092169550 cites W2054638358 @default.
• W2092169550 cites W2062315382 @default.
• W2092169550 cites W2064627520 @default.
• W2092169550 cites W2066529195 @default.
• W2092169550 cites W2069444054 @default.
• W2092169550 cites W2074713306 @default.
• W2092169550 cites W2079594748 @default.
• W2092169550 cites W2088571368 @default.
• W2092169550 cites W2110581720 @default.
• W2092169550 cites W2117043005 @default.
• W2092169550 cites W2124508454 @default.
• W2092169550 cites W2128963767 @default.
• W2092169550 cites W2131554133 @default.
• W2092169550 cites W2132485651 @default.
• W2092169550 cites W2135709160 @default.
• W2092169550 cites W2136418873 @default.
• W2092169550 cites W2152396103 @default.
• W2092169550 cites W2154346498 @default.
• W2092169550 cites W2154374454 @default.
• W2092169550 cites W223415719 @default.
• W2092169550 cites W2316160054 @default.
• W2092169550 cites W4239456483 @default.
• W2092169550 cites W4254123044 @default.
• W2092169550 cites W4313333674 @default.
• W2092169550 doi "https://doi.org/10.1158/0008-5472.can-04-0124" @default.
• W2092169550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15492276" @default.
• W2092169550 hasPublicationYear "2004" @default.
• W2092169550 type Work @default.
• W2092169550 sameAs 2092169550 @default.
• W2092169550 citedByCount "79" @default.
• W2092169550 countsByYear W20921695502012 @default.
• W2092169550 countsByYear W20921695502013 @default.
• W2092169550 countsByYear W20921695502014 @default.
• W2092169550 countsByYear W20921695502015 @default.
• W2092169550 countsByYear W20921695502016 @default.
• W2092169550 countsByYear W20921695502017 @default.
• W2092169550 countsByYear W20921695502018 @default.
• W2092169550 countsByYear W20921695502019 @default.
• W2092169550 countsByYear W20921695502020 @default.
• W2092169550 countsByYear W20921695502021 @default.
• W2092169550 countsByYear W20921695502023 @default.
• W2092169550 crossrefType "journal-article" @default.
• W2092169550 hasAuthorship W2092169550A5006765393 @default.
• W2092169550 hasAuthorship W2092169550A5007023688 @default.
• W2092169550 hasAuthorship W2092169550A5024034724 @default.
• W2092169550 hasAuthorship W2092169550A5032464400 @default.
• W2092169550 hasAuthorship W2092169550A5034151974 @default.
• W2092169550 hasAuthorship W2092169550A5043526996 @default.
• W2092169550 hasAuthorship W2092169550A5055955432 @default.
• W2092169550 hasAuthorship W2092169550A5059167270 @default.
• W2092169550 hasAuthorship W2092169550A5078548012 @default.
• W2092169550 hasAuthorship W2092169550A5091207345 @default.
• W2092169550 hasBestOaLocation W20921695501 @default.
• W2092169550 hasConcept C11960822 @default.
• W2092169550 hasConcept C137738243 @default.
• W2092169550 hasConcept C1491633281 @default.
• W2092169550 hasConcept C167734588 @default.
• W2092169550 hasConcept C185592680 @default.
• W2092169550 hasConcept C203014093 @default.
• W2092169550 hasConcept C27740335 @default.
• W2092169550 hasConcept C2776364478 @default.

• next