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• W2092175013 endingPage "026006" @default.
• W2092175013 startingPage "026006" @default.
• W2092175013 abstract "We mapped promoter regions of double-stranded DNA with respect to the probabilities of appearance of relatively large bubble openings exclusively due to thermal fluctuations at physiological temperatures. We analyzed five well-studied promoter regions of procaryotic type and found a spatial correlation between the binding sites of transcription factors and the position of peaks in the probability pattern of large thermal openings. Other distinct peaks of the calculated patterns correlate with potential binding sites of DNA-binding proteins. These results suggest that a DNA molecule would more frequently expose the bases that participate in contacts with proteins, which would probably enhance the probability of the latter to reach their targets. It also stands for using this method as a means to analyze DNA sequences based on their intrinsic thermal properties." @default.
• W2092175013 created "2016-06-24" @default.
• W2092175013 creator A5061156190 @default.
• W2092175013 creator A5068569143 @default.
• W2092175013 date "2011-01-24" @default.
• W2092175013 modified "2023-09-23" @default.
• W2092175013 title "Targets of DNA-binding proteins in bacterial promoter regions present enhanced probabilities for spontaneous thermal openings" @default.
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• W2092175013 doi "https://doi.org/10.1088/1478-3975/8/2/026006" @default.
• W2092175013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21263165" @default.
• W2092175013 hasPublicationYear "2011" @default.
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