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• W2092180535 abstract "Although eukaryotic cells are known to alternate between “advancing” episodes of fast and persistent movement and “hesitation” episodes of low speed and low persistence, the molecular mechanism that controls the dynamic changes in morphology, speed, and persistence of eukaryotic migratory cells remains unclear. Here, we show that the movement of the interphase nucleus during random cell migration switches intermittently between two distinct modes - rotation and translocation - that follow with high fidelity the sequential rounded and elongated morphologies of the nucleus and cell body, respectively. Nuclear rotation and translocation respectively mediate the stop-and-go motion of the cell through the dynamic formation and dissolution of the contractile perinuclear actin cap, which is dynamically coupled to the nuclear lamina and the nuclear envelope through LINC complexes. A persistent cell movement and nuclear translocation driven by the actin cap are halted following the disruption of the actin cap, which in turn allows the cell to repolarize for its next persistent move thanks to nuclear rotation mediated by cytoplasmic dynein light intermediate chain 2." @default.
• W2092180535 created "2016-06-24" @default.
• W2092180535 creator A5003835601 @default.
• W2092180535 creator A5048842521 @default.
• W2092180535 creator A5084215859 @default.
• W2092180535 date "2014-01-01" @default.
• W2092180535 modified "2023-10-17" @default.
• W2092180535 title "Tight coupling between nucleus and cell migration through the perinuclear actin cap" @default.
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• W2092180535 doi "https://doi.org/10.1242/jcs.144345" @default.
• W2092180535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4038945" @default.
• W2092180535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24639463" @default.
• W2092180535 hasPublicationYear "2014" @default.
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