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• W2092180537 abstract "We investigated the functional roles of presynaptic GABAA receptors on excitatory nerve terminals in contributing to spontaneous and action potential-evoked glutamatergic transmission to rat hippocampal CA3 pyramidal neurons. Single CA3 neurons were mechanically isolated with adherent nerve terminals, namely the ‘synaptic bouton preparation’, and spontaneous glutamatergic excitatory synaptic potentials (sEPSCs) and EPSCs evoked by focal electrical stimuli of a single presynaptic glutamatergic boutons (eEPSCs) were recorded using conventional whole-cell patch recordings. Selective activation of presynaptic GABAA receptors on these excitatory nerve terminals by muscimol, markedly facilitated sEPSCs frequency but inhibited eEPSC amplitude. The facilitation of sEPSC frequency was completely occluded by GABAA receptor–Cl− channel blockers bicuculline or penicillin (PN). PN itself concentration-dependently inhibited the GABAA receptor response induced by bath application of muscimol, but had no effect on the glutamate receptor response. In addition, pretreatment with a blocker of the Na+, K+, 2Cl− co-transporter type 1 (NKCC-1), bumetanide, prevented the muscimol-induced inhibition of eEPSCs. The results indicate that activation of presynaptic GABAA receptors directly depolarizes glutamatergic excitatory nerve terminals and thereby differentially modulates sEPSCs and eEPSCs." @default.
• W2092180537 created "2016-06-24" @default.
• W2092180537 creator A5001368432 @default.
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• W2092180537 date "2011-01-01" @default.
• W2092180537 modified "2023-10-18" @default.
• W2092180537 title "GABAA receptor-mediated presynaptic inhibition on glutamatergic transmission" @default.
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• W2092180537 doi "https://doi.org/10.1016/j.brainresbull.2010.10.007" @default.
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