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- W2092183917 endingPage "498" @default.
- W2092183917 startingPage "489" @default.
- W2092183917 abstract "Abstract Despite significant progress in our understanding of the pathogenesis and etiology of periodontal diseases, the nature and contribution of the immune system to this disorder remains unclear. Several studies provide evidence for either a protective or destructive rôle. These conflicting findings are difficult to reconcile, since most interpretations tend to argue for a static contributory rôle (i.e., either protective or destructive) of the immune system. Current theories on the role of the immune response do not address these conflicting findings as well as the contradictory observation of a delectable immune response in the face of persistent infection in these patients. In this article, we present a model, based on available data, for the contribution of the immune system to the pathogenesis of periodontal disease. This model ascribes a dynamic role for the immune response. As documented in other infectious diseases, it is entirely possible, for example, that a state of immunologic dysfunction may occur in the earliest stages of periodontal disease progression; this may then be followed by a period of active immune reactivity (humoral and/or cellular) that would represent either a delayed or depressed response. This model is discussed in conjunction with recent findings that several suspected periodontal pathogens are capable of producing immuno-suppressive agents. Many of the apparently contradictory clinical observations concerning the host immune response to oral pathogens and its correlation (or lack of) with both the progression and severity of periodontal disease may be accounted for in this model." @default.
- W2092183917 created "2016-06-24" @default.
- W2092183917 creator A5087731817 @default.
- W2092183917 date "1987-10-01" @default.
- W2092183917 modified "2023-09-26" @default.
- W2092183917 title "Immunologic dysfunction in the pathogenesis of periodontal diseases*" @default.
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