FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092185375> ?p ?o ?g. }

• W2092185375 endingPage "7" @default.
• W2092185375 startingPage "3" @default.
• W2092185375 abstract "Abstract The receptors that couple to G proteins (GPCR) and which span the cell membranes seven times (7‐TM receptors) were the focus of a symposium in Stockholm 2006. The ensemble of GPCR has now been mapped in several animal species. They remain a major focus of interest in drug development, and their diverse physiological and pathophysiological roles are being clarified, i.a. by genetic targeting. Recent developments hint at novel levels of complexity. First, many, if not all, GPCRs are part of multimeric ensembles, and physiology and pharmacology of a given GPCR may be at least partly guided by the partners it was formed together with. Secondly, at least some GPCRs may be constitutively active. Therefore, drugs that are inverse agonists may prove useful. Furthermore, the level of activity may vary in such a profound way between cells and tissues that this could offer new ways of achieving specificity of drug action. Finally, it is becoming increasingly clear that some of these receptors can signal via novel types of pathways, and hence that ‘GPCRs’ may not always be G‐protein‐coupled. Thus there are many challenges for the basic scientist and the drug industry." @default.
• W2092185375 created "2016-06-24" @default.
• W2092185375 creator A5008327136 @default.
• W2092185375 creator A5051585961 @default.
• W2092185375 creator A5077494149 @default.
• W2092185375 date "2007-04-05" @default.
• W2092185375 modified "2023-10-17" @default.
• W2092185375 title "G-protein-coupled receptors: an update" @default.
• W2092185375 cites W1571586310 @default.
• W2092185375 cites W1590468936 @default.
• W2092185375 cites W1964645795 @default.
• W2092185375 cites W1966101832 @default.
• W2092185375 cites W1968902143 @default.
• W2092185375 cites W1974340289 @default.
• W2092185375 cites W1974906202 @default.
• W2092185375 cites W1979923215 @default.
• W2092185375 cites W1984429646 @default.
• W2092185375 cites W1991950974 @default.
• W2092185375 cites W2002514583 @default.
• W2092185375 cites W2007149985 @default.
• W2092185375 cites W2007244994 @default.
• W2092185375 cites W2010805571 @default.
• W2092185375 cites W2023249904 @default.
• W2092185375 cites W2023939486 @default.
• W2092185375 cites W2025046733 @default.
• W2092185375 cites W2030152049 @default.
• W2092185375 cites W2032790231 @default.
• W2092185375 cites W2037328290 @default.
• W2092185375 cites W2038540431 @default.
• W2092185375 cites W2046402357 @default.
• W2092185375 cites W2069915228 @default.
• W2092185375 cites W2070849419 @default.
• W2092185375 cites W2071327910 @default.
• W2092185375 cites W2072532414 @default.
• W2092185375 cites W2074844667 @default.
• W2092185375 cites W2076889177 @default.
• W2092185375 cites W2079052124 @default.
• W2092185375 cites W2080815758 @default.
• W2092185375 cites W2101738153 @default.
• W2092185375 cites W2105840785 @default.
• W2092185375 cites W2107730819 @default.
• W2092185375 cites W2117008929 @default.
• W2092185375 cites W2125381530 @default.
• W2092185375 cites W2126651811 @default.
• W2092185375 cites W2132728479 @default.
• W2092185375 cites W2135585584 @default.
• W2092185375 cites W2147613694 @default.
• W2092185375 cites W2149963584 @default.
• W2092185375 cites W2153940484 @default.
• W2092185375 cites W2158606064 @default.
• W2092185375 cites W2160119905 @default.
• W2092185375 cites W2171756360 @default.
• W2092185375 cites W2312328575 @default.
• W2092185375 cites W3025891904 @default.
• W2092185375 doi "https://doi.org/10.1111/j.1365-201x.2007.01689.x" @default.
• W2092185375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428227" @default.
• W2092185375 hasPublicationYear "2007" @default.
• W2092185375 type Work @default.
• W2092185375 sameAs 2092185375 @default.
• W2092185375 citedByCount "40" @default.
• W2092185375 countsByYear W20921853752012 @default.
• W2092185375 countsByYear W20921853752013 @default.
• W2092185375 countsByYear W20921853752014 @default.
• W2092185375 countsByYear W20921853752015 @default.
• W2092185375 countsByYear W20921853752016 @default.
• W2092185375 crossrefType "journal-article" @default.
• W2092185375 hasAuthorship W2092185375A5008327136 @default.
• W2092185375 hasAuthorship W2092185375A5051585961 @default.
• W2092185375 hasAuthorship W2092185375A5077494149 @default.
• W2092185375 hasConcept C135285700 @default.
• W2092185375 hasConcept C169760540 @default.
• W2092185375 hasConcept C170493617 @default.
• W2092185375 hasConcept C2780035454 @default.
• W2092185375 hasConcept C54355233 @default.
• W2092185375 hasConcept C60644358 @default.
• W2092185375 hasConcept C64903051 @default.
• W2092185375 hasConcept C70721500 @default.
• W2092185375 hasConcept C74187038 @default.
• W2092185375 hasConcept C86380466 @default.
• W2092185375 hasConcept C86803240 @default.
• W2092185375 hasConcept C98274493 @default.
• W2092185375 hasConceptScore W2092185375C135285700 @default.
• W2092185375 hasConceptScore W2092185375C169760540 @default.
• W2092185375 hasConceptScore W2092185375C170493617 @default.
• W2092185375 hasConceptScore W2092185375C2780035454 @default.
• W2092185375 hasConceptScore W2092185375C54355233 @default.
• W2092185375 hasConceptScore W2092185375C60644358 @default.
• W2092185375 hasConceptScore W2092185375C64903051 @default.
• W2092185375 hasConceptScore W2092185375C70721500 @default.
• W2092185375 hasConceptScore W2092185375C74187038 @default.
• W2092185375 hasConceptScore W2092185375C86380466 @default.
• W2092185375 hasConceptScore W2092185375C86803240 @default.
• W2092185375 hasConceptScore W2092185375C98274493 @default.
• W2092185375 hasIssue "1" @default.
• W2092185375 hasLocation W20921853751 @default.
• W2092185375 hasLocation W20921853752 @default.
• W2092185375 hasOpenAccess W2092185375 @default.
• W2092185375 hasPrimaryLocation W20921853751 @default.

• next