FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092185728> ?p ?o ?g. }

• W2092185728 endingPage "366" @default.
• W2092185728 startingPage "356" @default.
• W2092185728 abstract "Agr2 is a disulfide isomerase residing in the endoplasmic reticulum (ER), which physiologically regulates protein folding and mediates resistance to ER stress. Agr2 is overexpressed in adenocarcinomas of various organs, where it participates in neoplastic transformation and metastasis, therefore acts as a pro-oncogenic protein. Besides its normal localization in the ER, Agr2 is also found in the serum and urine of cancer patients, although the physiological significance of extracellular Agr2 is poorly understood. In this study, we demonstrated that extracellular Agr2 can activate stromal fibroblasts and promote fibroblast-associated cancer invasion in gastric signet-ring cell carcinoma (SRCC), where Agr2 is highly expressed. Agr2 secreted from SRCC cells was incorporated by the surrounding gastric fibroblasts and promoted invasion by these cells. In turn, activated fibroblasts coordinated the invasive behavior of fibroblasts and cancer cells. Our findings suggested that Agr2 drives progression of gastric SRCC by exerting paracrine effects on fibroblasts in the tumor microenvironment, acting also to increase the growth and resistance of SRCC cells to oxidative and hypoxic stress as cell autonomous effects." @default.
• W2092185728 created "2016-06-24" @default.
• W2092185728 creator A5000366018 @default.
• W2092185728 creator A5008459293 @default.
• W2092185728 creator A5019744439 @default.
• W2092185728 creator A5020219831 @default.
• W2092185728 creator A5022342891 @default.
• W2092185728 creator A5024970639 @default.
• W2092185728 creator A5033853031 @default.
• W2092185728 creator A5037469756 @default.
• W2092185728 creator A5053041120 @default.
• W2092185728 creator A5089607790 @default.
• W2092185728 date "2015-01-14" @default.
• W2092185728 modified "2023-09-26" @default.
• W2092185728 title "Agr2 Mediates Paracrine Effects on Stromal Fibroblasts That Promote Invasion by Gastric Signet-Ring Carcinoma Cells" @default.
• W2092185728 cites W1964668335 @default.
• W2092185728 cites W1974546347 @default.
• W2092185728 cites W1980770051 @default.
• W2092185728 cites W1989071293 @default.
• W2092185728 cites W1989531492 @default.
• W2092185728 cites W1994919628 @default.
• W2092185728 cites W1999981067 @default.
• W2092185728 cites W2010149759 @default.
• W2092185728 cites W2012374763 @default.
• W2092185728 cites W2026630660 @default.
• W2092185728 cites W2027260954 @default.
• W2092185728 cites W2029010044 @default.
• W2092185728 cites W2031486793 @default.
• W2092185728 cites W2033479986 @default.
• W2092185728 cites W2035966539 @default.
• W2092185728 cites W2037272933 @default.
• W2092185728 cites W2052545791 @default.
• W2092185728 cites W2052565055 @default.
• W2092185728 cites W2076370383 @default.
• W2092185728 cites W2079274834 @default.
• W2092185728 cites W2079332479 @default.
• W2092185728 cites W2081341738 @default.
• W2092185728 cites W2091616531 @default.
• W2092185728 cites W2095744362 @default.
• W2092185728 cites W2096889391 @default.
• W2092185728 cites W2098771435 @default.
• W2092185728 cites W2114024312 @default.
• W2092185728 cites W2122753551 @default.
• W2092185728 cites W2125407220 @default.
• W2092185728 cites W2143571146 @default.
• W2092185728 cites W2155536841 @default.
• W2092185728 cites W2171319435 @default.
• W2092185728 cites W2171797678 @default.
• W2092185728 cites W2191186525 @default.
• W2092185728 cites W2338576041 @default.
• W2092185728 cites W4231021828 @default.
• W2092185728 doi "https://doi.org/10.1158/0008-5472.can-14-1693" @default.
• W2092185728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25488752" @default.
• W2092185728 hasPublicationYear "2015" @default.
• W2092185728 type Work @default.
• W2092185728 sameAs 2092185728 @default.
• W2092185728 citedByCount "31" @default.
• W2092185728 countsByYear W20921857282015 @default.
• W2092185728 countsByYear W20921857282016 @default.
• W2092185728 countsByYear W20921857282017 @default.
• W2092185728 countsByYear W20921857282018 @default.
• W2092185728 countsByYear W20921857282019 @default.
• W2092185728 countsByYear W20921857282020 @default.
• W2092185728 countsByYear W20921857282021 @default.
• W2092185728 countsByYear W20921857282022 @default.
• W2092185728 countsByYear W20921857282023 @default.
• W2092185728 crossrefType "journal-article" @default.
• W2092185728 hasAuthorship W2092185728A5000366018 @default.
• W2092185728 hasAuthorship W2092185728A5008459293 @default.
• W2092185728 hasAuthorship W2092185728A5019744439 @default.
• W2092185728 hasAuthorship W2092185728A5020219831 @default.
• W2092185728 hasAuthorship W2092185728A5022342891 @default.
• W2092185728 hasAuthorship W2092185728A5024970639 @default.
• W2092185728 hasAuthorship W2092185728A5033853031 @default.
• W2092185728 hasAuthorship W2092185728A5037469756 @default.
• W2092185728 hasAuthorship W2092185728A5053041120 @default.
• W2092185728 hasAuthorship W2092185728A5089607790 @default.
• W2092185728 hasBestOaLocation W20921857281 @default.
• W2092185728 hasConcept C111798993 @default.
• W2092185728 hasConcept C121608353 @default.
• W2092185728 hasConcept C139447449 @default.
• W2092185728 hasConcept C158617107 @default.
• W2092185728 hasConcept C16930146 @default.
• W2092185728 hasConcept C170493617 @default.
• W2092185728 hasConcept C2779013556 @default.
• W2092185728 hasConcept C2780381497 @default.
• W2092185728 hasConcept C28406088 @default.
• W2092185728 hasConcept C2909706936 @default.
• W2092185728 hasConcept C502942594 @default.
• W2092185728 hasConcept C54355233 @default.
• W2092185728 hasConcept C55493867 @default.
• W2092185728 hasConcept C7876069 @default.
• W2092185728 hasConcept C81885089 @default.
• W2092185728 hasConcept C86803240 @default.
• W2092185728 hasConcept C95444343 @default.
• W2092185728 hasConcept C96232424 @default.
• W2092185728 hasConceptScore W2092185728C111798993 @default.
• W2092185728 hasConceptScore W2092185728C121608353 @default.

• next