Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092185931> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2092185931 endingPage "657" @default.
- W2092185931 startingPage "650" @default.
- W2092185931 abstract "Polychlorinated biphenyls (PCBs) decrease thyroid function in laboratory rodents by inducing activity of a liver enzyme, uridine diphosphate-glucuronosyltransferase (UDP-GT), thereby increasing thyroxine (T4) clearance. This loss of T4 can lead to hypothyroidism. In this study, an assay was validated for measuring UDP-GT activity toward T4 in Japanese quail. UDP-GT induction by Aroclor 1254 was evaluated in quail, and responses of quail and mice were compared. In Experiment 1, Japanese quail and Balb/c mice were dosed orally with vehicle or Aroclor 1254 (250 or 500 mg/kg) and sacrificed 5 days later. In Experiment 2, Japanese quail were dosed orally with vehicle or Aroclor 1254 (500 mg/kg) and sacrificed 5 or 21 days later. UDP-GT capacity (pmol T4 glucuronidated by the liver/min per g body weight) increased with PCB exposure with all doses and exposure times in both species. Plasma T4 tended to decrease (not significant) with both PCB doses and exposure times in quail and was significantly decreased with both doses in mice. Quail did not become hypothyroid at either dose or exposure time. In contrast, mice did become hypothyroid after a 5-day exposure. It is unclear how PCBs affect the hypothalamic–pituitary–thyroid (HPT) axis in quail, but activation of the HPT axis appears to be inhibited in mice. We believe this is the first demonstration of a T4-specific, avian UDP-GT response to PCBs. However, this avian response was less than that in mice with equivalent doses of PCBs. Thus, thyroid function in birds appears to be less vulnerable to PCBs than in mammals." @default.
- W2092185931 created "2016-06-24" @default.
- W2092185931 creator A5001481960 @default.
- W2092185931 creator A5066728154 @default.
- W2092185931 date "2008-02-01" @default.
- W2092185931 modified "2023-09-27" @default.
- W2092185931 title "Polychlorinated biphenyl effects on avian hepatic enzyme induction and thyroid function" @default.
- W2092185931 cites W1968999818 @default.
- W2092185931 cites W1969370493 @default.
- W2092185931 cites W1974522774 @default.
- W2092185931 cites W1975349739 @default.
- W2092185931 cites W1976228062 @default.
- W2092185931 cites W1988005427 @default.
- W2092185931 cites W1988255049 @default.
- W2092185931 cites W1996708401 @default.
- W2092185931 cites W2012482676 @default.
- W2092185931 cites W2015056064 @default.
- W2092185931 cites W2022473332 @default.
- W2092185931 cites W2026408086 @default.
- W2092185931 cites W2031950184 @default.
- W2092185931 cites W2033559708 @default.
- W2092185931 cites W2040573969 @default.
- W2092185931 cites W2053645764 @default.
- W2092185931 cites W2053841433 @default.
- W2092185931 cites W2059977419 @default.
- W2092185931 cites W2064192817 @default.
- W2092185931 cites W2091675101 @default.
- W2092185931 cites W2096872918 @default.
- W2092185931 cites W2104284672 @default.
- W2092185931 cites W2117864144 @default.
- W2092185931 cites W2153393848 @default.
- W2092185931 doi "https://doi.org/10.1016/j.ygcen.2007.09.010" @default.
- W2092185931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17950733" @default.
- W2092185931 hasPublicationYear "2008" @default.
- W2092185931 type Work @default.
- W2092185931 sameAs 2092185931 @default.
- W2092185931 citedByCount "27" @default.
- W2092185931 countsByYear W20921859312012 @default.
- W2092185931 countsByYear W20921859312014 @default.
- W2092185931 countsByYear W20921859312015 @default.
- W2092185931 countsByYear W20921859312016 @default.
- W2092185931 countsByYear W20921859312018 @default.
- W2092185931 countsByYear W20921859312019 @default.
- W2092185931 countsByYear W20921859312020 @default.
- W2092185931 countsByYear W20921859312022 @default.
- W2092185931 crossrefType "journal-article" @default.
- W2092185931 hasAuthorship W2092185931A5001481960 @default.
- W2092185931 hasAuthorship W2092185931A5066728154 @default.
- W2092185931 hasBestOaLocation W20921859312 @default.
- W2092185931 hasConcept C126322002 @default.
- W2092185931 hasConcept C134018914 @default.
- W2092185931 hasConcept C18903297 @default.
- W2092185931 hasConcept C2776365360 @default.
- W2092185931 hasConcept C2777882087 @default.
- W2092185931 hasConcept C2778303931 @default.
- W2092185931 hasConcept C2993291352 @default.
- W2092185931 hasConcept C526584372 @default.
- W2092185931 hasConcept C71924100 @default.
- W2092185931 hasConcept C86803240 @default.
- W2092185931 hasConceptScore W2092185931C126322002 @default.
- W2092185931 hasConceptScore W2092185931C134018914 @default.
- W2092185931 hasConceptScore W2092185931C18903297 @default.
- W2092185931 hasConceptScore W2092185931C2776365360 @default.
- W2092185931 hasConceptScore W2092185931C2777882087 @default.
- W2092185931 hasConceptScore W2092185931C2778303931 @default.
- W2092185931 hasConceptScore W2092185931C2993291352 @default.
- W2092185931 hasConceptScore W2092185931C526584372 @default.
- W2092185931 hasConceptScore W2092185931C71924100 @default.
- W2092185931 hasConceptScore W2092185931C86803240 @default.
- W2092185931 hasIssue "3" @default.
- W2092185931 hasLocation W20921859311 @default.
- W2092185931 hasLocation W20921859312 @default.
- W2092185931 hasLocation W20921859313 @default.
- W2092185931 hasOpenAccess W2092185931 @default.
- W2092185931 hasPrimaryLocation W20921859311 @default.
- W2092185931 hasRelatedWork W1988955289 @default.
- W2092185931 hasRelatedWork W2017252830 @default.
- W2092185931 hasRelatedWork W2030363005 @default.
- W2092185931 hasRelatedWork W2050439257 @default.
- W2092185931 hasRelatedWork W2053362447 @default.
- W2092185931 hasRelatedWork W2059576128 @default.
- W2092185931 hasRelatedWork W2070295037 @default.
- W2092185931 hasRelatedWork W2086258991 @default.
- W2092185931 hasRelatedWork W2092185931 @default.
- W2092185931 hasRelatedWork W2110261522 @default.
- W2092185931 hasVolume "155" @default.
- W2092185931 isParatext "false" @default.
- W2092185931 isRetracted "false" @default.
- W2092185931 magId "2092185931" @default.
- W2092185931 workType "article" @default.