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- W2092188577 abstract "The non-specific heparin thrombin clotting time of plasma (HTCT) is consistently abnormal in thrombosis and is thought to reflect platelet activation with release of heparin neutralizing activity (HNA). Twenty one volunteers were studied usually every 14 days for 5 months. All upper respiratory tract infections were reported; and then more frequent studies were made. These minor illnesses were graded as “mild”, “moderate” or “severe”. In health the HTCT remained remarkably constant, but with marked between-person differences. In 11 of the 13 “severe” illnesses the HTCT was significantly short and the HTCTs were shortest in “severe” illnesses. While studies reported here show that fibrinogen has little or no effect on the HTCT, nevertheless the HTCT was correlated with the fibrinogen level but not with any of the many other acute phase proteins studied intensively in one volunteer. These findings suggest that platelets are involved or “activated” by quite minor infections and may play a special part in the acute phase reaction." @default.
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- W2092188577 date "1980-07-01" @default.
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- W2092188577 title "The effect of minor illness on the heparin thrombin clotting time" @default.
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- W2092188577 doi "https://doi.org/10.1016/0049-3848(80)90403-x" @default.
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