Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092195220> ?p ?o ?g. }
- W2092195220 endingPage "5568" @default.
- W2092195220 startingPage "5555" @default.
- W2092195220 abstract "The limited proteolysis of Cubitus interruptus (Ci), the transcription factor for the developmentally and medically important Hedgehog (Hh) signaling pathway, triggers a critical switch between transcriptional repressor and activator forms. Ci repressor is formed when the C terminus of full-length Ci is degraded by the ubiquitin-proteasome pathway, an unusual reaction since the proteasome typically completely degrades its substrates. We show that several regions of Ci are required for generation of the repressor form: the zinc finger DNA binding domain, a single lysine residue (K750) near the degradation end point, and a 163-amino-acid region at the C terminus. Unlike other proteins that are partially degraded by the proteasome, dimerization is not a key feature of Ci processing. Using a pulse-chase assay in cultured Drosophila cells, we distinguish between regions required for initiation of degradation and those required for the protection of the Ci N terminus from degradation. We present a model whereby the zinc finger region and K750 together form a unique protection signal that prevents the complete degradation of Ci by the proteasome." @default.
- W2092195220 created "2016-06-24" @default.
- W2092195220 creator A5000257282 @default.
- W2092195220 creator A5029941351 @default.
- W2092195220 date "2008-09-01" @default.
- W2092195220 modified "2023-09-25" @default.
- W2092195220 title "A Unique Protection Signal in Cubitus interruptus Prevents Its Complete Proteasomal Degradation" @default.
- W2092195220 cites W1513332069 @default.
- W2092195220 cites W1530130622 @default.
- W2092195220 cites W1575215071 @default.
- W2092195220 cites W1580962701 @default.
- W2092195220 cites W1593616223 @default.
- W2092195220 cites W1659071674 @default.
- W2092195220 cites W172906062 @default.
- W2092195220 cites W1965198797 @default.
- W2092195220 cites W1973892237 @default.
- W2092195220 cites W1976988264 @default.
- W2092195220 cites W1977203585 @default.
- W2092195220 cites W1979485381 @default.
- W2092195220 cites W1990675389 @default.
- W2092195220 cites W1998777048 @default.
- W2092195220 cites W2002312465 @default.
- W2092195220 cites W2012548477 @default.
- W2092195220 cites W2015299422 @default.
- W2092195220 cites W2017826121 @default.
- W2092195220 cites W2024639098 @default.
- W2092195220 cites W2025131311 @default.
- W2092195220 cites W2027728353 @default.
- W2092195220 cites W2034804054 @default.
- W2092195220 cites W2045862320 @default.
- W2092195220 cites W2045947221 @default.
- W2092195220 cites W2055864348 @default.
- W2092195220 cites W2056692294 @default.
- W2092195220 cites W2059640942 @default.
- W2092195220 cites W2061840465 @default.
- W2092195220 cites W2076517048 @default.
- W2092195220 cites W2082970676 @default.
- W2092195220 cites W2094092533 @default.
- W2092195220 cites W2094809543 @default.
- W2092195220 cites W2096343699 @default.
- W2092195220 cites W2101759139 @default.
- W2092195220 cites W2101859789 @default.
- W2092195220 cites W2108707301 @default.
- W2092195220 cites W2110753649 @default.
- W2092195220 cites W2115218796 @default.
- W2092195220 cites W2116903696 @default.
- W2092195220 cites W2122551230 @default.
- W2092195220 cites W2131686724 @default.
- W2092195220 cites W2159471546 @default.
- W2092195220 cites W2161996750 @default.
- W2092195220 cites W2162795835 @default.
- W2092195220 cites W2163288549 @default.
- W2092195220 cites W2163664843 @default.
- W2092195220 cites W2163838718 @default.
- W2092195220 cites W2168256871 @default.
- W2092195220 cites W2170048206 @default.
- W2092195220 cites W2171802796 @default.
- W2092195220 cites W2397804208 @default.
- W2092195220 doi "https://doi.org/10.1128/mcb.00524-08" @default.
- W2092195220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2546926" @default.
- W2092195220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18625727" @default.
- W2092195220 hasPublicationYear "2008" @default.
- W2092195220 type Work @default.
- W2092195220 sameAs 2092195220 @default.
- W2092195220 citedByCount "24" @default.
- W2092195220 countsByYear W20921952202012 @default.
- W2092195220 countsByYear W20921952202013 @default.
- W2092195220 countsByYear W20921952202014 @default.
- W2092195220 countsByYear W20921952202016 @default.
- W2092195220 countsByYear W20921952202019 @default.
- W2092195220 countsByYear W20921952202020 @default.
- W2092195220 countsByYear W20921952202021 @default.
- W2092195220 countsByYear W20921952202023 @default.
- W2092195220 crossrefType "journal-article" @default.
- W2092195220 hasAuthorship W2092195220A5000257282 @default.
- W2092195220 hasAuthorship W2092195220A5029941351 @default.
- W2092195220 hasBestOaLocation W20921952202 @default.
- W2092195220 hasConcept C104317684 @default.
- W2092195220 hasConcept C134459356 @default.
- W2092195220 hasConcept C158448853 @default.
- W2092195220 hasConcept C181199279 @default.
- W2092195220 hasConcept C24284526 @default.
- W2092195220 hasConcept C25602115 @default.
- W2092195220 hasConcept C27740335 @default.
- W2092195220 hasConcept C2781307694 @default.
- W2092195220 hasConcept C55493867 @default.
- W2092195220 hasConcept C86339819 @default.
- W2092195220 hasConcept C86803240 @default.
- W2092195220 hasConcept C94966510 @default.
- W2092195220 hasConcept C95444343 @default.
- W2092195220 hasConceptScore W2092195220C104317684 @default.
- W2092195220 hasConceptScore W2092195220C134459356 @default.
- W2092195220 hasConceptScore W2092195220C158448853 @default.
- W2092195220 hasConceptScore W2092195220C181199279 @default.
- W2092195220 hasConceptScore W2092195220C24284526 @default.
- W2092195220 hasConceptScore W2092195220C25602115 @default.
- W2092195220 hasConceptScore W2092195220C27740335 @default.
- W2092195220 hasConceptScore W2092195220C2781307694 @default.