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- W2092200928 abstract "Data have been produced on the parameters which influence the development of internal stresses within aqueous HPMC film coats plasticized with glycerol in an attempt to calculate the magnitude of internal stress generation. Films have been prepared under conditions which equate to those experienced during film coating processes. The changes in mechanical and thermal properties of fresh films formed at different tablet bed conditions have been studied during their ambient storage. The contribution of internal stresses from three sources are calculated individually and a single equation is used to estimate the total internal stress within a film. This equation considers the contribution made by the volumetric changes of the tablet core during ambient conditions in addition to those caused by other well-established mechanisms. The results of these calculations showed that the total internal stress is influenced, not only by these volumetric changes, but also by the conditions in which the film coating process was performed. The possibility of the film coating undergoing failure is also discussed." @default.
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- W2092200928 date "1995-06-01" @default.
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- W2092200928 title "Quantitative estimation of internal stress development in aqueous HPMC tablet film coats" @default.
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- W2092200928 doi "https://doi.org/10.1016/0378-5173(94)00393-j" @default.
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