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• W2092202008 abstract "The mineralocorticoid aldosterone plays an important role in the regulation of plasma electrolyte homeostasis. Exposure of acutely isolated rat adrenal zona glomerulosa cells to elevated K+ activates voltage-gated calcium channels and initiates a calcium-dependent increase in aldosterone synthesis. We developed a novel 96-well format aldosterone secretion assay to rapidly evaluate the effect of known T- and L-type calcium channel antagonists on K+-stimulated aldosterone secretion and better define the role of voltage-gated calcium channels in this process. Reported T-type antagonists, mibefradil and Ni2+, and selected L-type antagonist dihydropyridines, inhibited K+-stimulated aldosterone synthesis. Dihydropyridine-mediated inhibition occurred at concentrations which had no effect on rat α1H T-type Ca2+ currents. In contrast, below 10 μM, the L-type antagonists verapamil and diltiazem showed only minimal inhibitory effects. To examine the selectivity of the calcium channel antagonist-mediated inhibition, we established an aldosterone secretion assay in which 8Br-cAMP stimulates aldosterone secretion independent of extracellular calcium. Mibefradil remained inhibitory in this assay, while the dihydropyridines had only limited effects. Taken together, these data demonstrate a role for the L-type calcium channel in K+-stimulated aldosterone secretion. Further, they confirm the need for selective T-type calcium channel antagonists to better address the role of T-type channels in K+-stimulated aldosterone secretion." @default.
• W2092202008 created "2016-06-24" @default.
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• W2092202008 creator A5068636357 @default.
• W2092202008 creator A5074296141 @default.
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• W2092202008 date "2004-10-01" @default.
• W2092202008 modified "2023-10-18" @default.
• W2092202008 title "Role of voltage-gated calcium channels in potassium-stimulated aldosterone secretion from rat adrenal zona glomerulosa cells" @default.
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• W2092202008 doi "https://doi.org/10.1016/j.jsbmb.2004.04.012" @default.
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