FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092202224> ?p ?o ?g. }

• W2092202224 endingPage "409" @default.
• W2092202224 startingPage "397" @default.
• W2092202224 abstract "The effects of non-nearest base sequences, beyond the nucleotides flanking a DNA lesion on either side, on nucleotide excision repair (NER) in extracts from human cells were investigated. We constructed two duplexes containing the same minor groove-aligned 10S (+)-trans-anti-B[a]P-N2-dG (G⁎) DNA adduct, derived from the environmental carcinogen benzo[a]pyrene (B[a]P): 5′-C-C-A-T-C-G⁎-C-T-A-C-C-3′ (CG⁎C-I), and 5′-C-A-C3-A4-C5-G⁎-C-A-C-A-C-3′ (CG⁎C-II). We used polyacrylamide gel electrophoresis to compare the extent of DNA bending, and molecular dynamics simulations to analyze the structural characteristics of these two DNA duplexes. The NER efficiencies are 1.6(± 0.2)-fold greater in the case of the CG⁎C-II than the CG⁎C-I sequence context in 135-mer duplexes. Gel electrophoresis and self-ligation circularization experiments revealed that the CG⁎C-II duplex is more bent than the CG⁎C-I duplex, while molecular dynamics simulations showed that the unique -C3-A4-C5- segment in the CG⁎C-II duplex plays a key role. The presence of a minor groove-positioned guanine amino group, the Watson–Crick partner to C3, acts as a wedge; facilitated by a highly deformable local -C3-A4- base step, this amino group allows the B[a]P ring system to produce a more enlarged minor groove in CG⁎C-II than in CG⁎C-I, as well as a local untwisting and enlarged and flexible Roll only in the CG⁎C-II sequence. These structural properties fit well with our earlier findings that in the case of the family of minor groove 10S (+)-trans-anti-B[a]P-N2-dG lesions, flexible bends and enlarged minor groove widths constitute NER recognition signals, and extend our understanding of sequence context effects on NER to the neighbors that are distant to the lesion." @default.
• W2092202224 created "2016-06-24" @default.
• W2092202224 creator A5005827361 @default.
• W2092202224 creator A5017005961 @default.
• W2092202224 creator A5018460703 @default.
• W2092202224 creator A5037216633 @default.
• W2092202224 creator A5037718394 @default.
• W2092202224 creator A5045073997 @default.
• W2092202224 creator A5048058203 @default.
• W2092202224 creator A5071938999 @default.
• W2092202224 creator A5076368300 @default.
• W2092202224 creator A5077706769 @default.
• W2092202224 date "2010-06-01" @default.
• W2092202224 modified "2023-09-30" @default.
• W2092202224 title "Distant Neighbor Base Sequence Context Effects in Human Nucleotide Excision Repair of a Benzo[a]pyrene-derived DNA Lesion" @default.
• W2092202224 cites W1515974446 @default.
• W2092202224 cites W1526944695 @default.
• W2092202224 cites W1809723721 @default.
• W2092202224 cites W1963658914 @default.
• W2092202224 cites W1966500537 @default.
• W2092202224 cites W1974691766 @default.
• W2092202224 cites W1978564348 @default.
• W2092202224 cites W1993244012 @default.
• W2092202224 cites W1995170368 @default.
• W2092202224 cites W1995995625 @default.
• W2092202224 cites W1999101994 @default.
• W2092202224 cites W1999163677 @default.
• W2092202224 cites W2000926230 @default.
• W2092202224 cites W2005912066 @default.
• W2092202224 cites W2005943555 @default.
• W2092202224 cites W2007709159 @default.
• W2092202224 cites W2013803515 @default.
• W2092202224 cites W2013823172 @default.
• W2092202224 cites W2016253703 @default.
• W2092202224 cites W2019204592 @default.
• W2092202224 cites W2020651808 @default.
• W2092202224 cites W2021578565 @default.
• W2092202224 cites W2028193482 @default.
• W2092202224 cites W2029470508 @default.
• W2092202224 cites W2031123552 @default.
• W2092202224 cites W2032471242 @default.
• W2092202224 cites W2032820551 @default.
• W2092202224 cites W2033355069 @default.
• W2092202224 cites W2038874225 @default.
• W2092202224 cites W2043382823 @default.
• W2092202224 cites W2044060614 @default.
• W2092202224 cites W2050680296 @default.
• W2092202224 cites W2053561906 @default.
• W2092202224 cites W2058461284 @default.
• W2092202224 cites W2060858846 @default.
• W2092202224 cites W2065545028 @default.
• W2092202224 cites W2066386477 @default.
• W2092202224 cites W2076091293 @default.
• W2092202224 cites W2081143798 @default.
• W2092202224 cites W2085128144 @default.
• W2092202224 cites W2094229567 @default.
• W2092202224 cites W2095994064 @default.
• W2092202224 cites W2112782571 @default.
• W2092202224 cites W2122247955 @default.
• W2092202224 cites W2127751112 @default.
• W2092202224 cites W2135731259 @default.
• W2092202224 cites W2139064328 @default.
• W2092202224 cites W2155338010 @default.
• W2092202224 cites W2170298709 @default.
• W2092202224 cites W4241673276 @default.
• W2092202224 doi "https://doi.org/10.1016/j.jmb.2010.04.004" @default.
• W2092202224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2923096" @default.
• W2092202224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20399214" @default.
• W2092202224 hasPublicationYear "2010" @default.
• W2092202224 type Work @default.
• W2092202224 sameAs 2092202224 @default.
• W2092202224 citedByCount "33" @default.
• W2092202224 countsByYear W20922022242012 @default.
• W2092202224 countsByYear W20922022242013 @default.
• W2092202224 countsByYear W20922022242015 @default.
• W2092202224 countsByYear W20922022242016 @default.
• W2092202224 countsByYear W20922022242017 @default.
• W2092202224 countsByYear W20922022242018 @default.
• W2092202224 countsByYear W20922022242019 @default.
• W2092202224 countsByYear W20922022242020 @default.
• W2092202224 countsByYear W20922022242021 @default.
• W2092202224 countsByYear W20922022242023 @default.
• W2092202224 crossrefType "journal-article" @default.
• W2092202224 hasAuthorship W2092202224A5005827361 @default.
• W2092202224 hasAuthorship W2092202224A5017005961 @default.
• W2092202224 hasAuthorship W2092202224A5018460703 @default.
• W2092202224 hasAuthorship W2092202224A5037216633 @default.
• W2092202224 hasAuthorship W2092202224A5037718394 @default.
• W2092202224 hasAuthorship W2092202224A5045073997 @default.
• W2092202224 hasAuthorship W2092202224A5048058203 @default.
• W2092202224 hasAuthorship W2092202224A5071938999 @default.
• W2092202224 hasAuthorship W2092202224A5076368300 @default.
• W2092202224 hasAuthorship W2092202224A5077706769 @default.
• W2092202224 hasBestOaLocation W20922022242 @default.
• W2092202224 hasConcept C104317684 @default.
• W2092202224 hasConcept C104451858 @default.
• W2092202224 hasConcept C114246631 @default.
• W2092202224 hasConcept C116084860 @default.

• next