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• W2092202938 endingPage "95" @default.
• W2092202938 startingPage "85" @default.
• W2092202938 abstract "The basic premises that guide genetic toxicity testing for identifying carcinogens and to support administrative and regulatory decisions are: the Salmonella mutagenicity test is a necessary component of testing schemes; a chromosome aberration test is needed in addition to a gene mutation test; a mammalian cell mutagenicity test is needed in addition to the Salmonella test;in vivotests are needed to confirm the results ofin vitrotests; and test batteries are more predictive than the individual tests of the battery. Results from the Salmonella mutagenicity,in vitrochromosome aberration, mutations in mouse lymphoma cells, rodent bone marrow micronucleus, and rodent carcinogenicity tests, performed by the U.S. National Toxicology Program, were used to evaluate these premises. A positive Salmonella test was most predictive of carcinogenicity. However, the data do not support using the other tests in addition to Salmonella for predicting carcinogenicity. The genetic toxicity tests did not complement each other, and batteries or combinations of the tests were no more predictive of carcinogenicity than Salmonella alone. If a chemical is mutagenic in Salmonella it should be considered a potential rodent carcinogen, unless ancillary information suggests otherwise. Positive responses in the otherin vitroorin vivotests do not increase the probability that the chemical is a carcinogen, and negative responses in the other tests do not diminish the implications of the positive Salmonella response." @default.
• W2092202938 created "2016-06-24" @default.
• W2092202938 creator A5028287356 @default.
• W2092202938 date "1998-10-01" @default.
• W2092202938 modified "2023-10-17" @default.
• W2092202938 title "Identification of Rodent Carcinogens and Noncarcinogens Using Genetic Toxicity Tests: Premises, Promises, and Performance" @default.
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• W2092202938 doi "https://doi.org/10.1006/rtph.1998.1234" @default.
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