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• W2092203867 abstract "The effects of Pacific ciguatoxin-4B (P-CTX-4B, also named gambiertoxin), extracted from toxic Gambierdiscus dinoflagellates, were assessed on nodal K+ and Na+ currents of frog myelinated axons, using a conventional voltage-clamp technique. P-CTX-4B decreased, within a few minutes, both K+ and Na+ currents in a dose-dependent manner, without inducing any marked change in current kinetics. The toxin was more effective in blocking K+ than Na+ channels. P-CTX-4B shifted the voltage-dependence of Na+ conductance by about 14 mV towards more negative membrane potentials. This effect was reversed by increasing Ca2+ in the external solution. A negative shift of about 16 mV in the steady-state Na+ inactivation-voltage curve was also observed in the presence of the toxin. Unmodified and P-CTX-4B-modified Na+ currents were similarly affected by the local anaesthetic lidocaine. The decrease of the two currents by lidocaine was dependent on both the concentration and the membrane potential during pre-pulses. In conclusion, P-CTX-4B appears about four times more effective than P-CTX-1B to affect K+ channels, whereas it is about 50 times less efficient to affect Na+ channels of axonal membranes. These actions may be related to subtle differences between the two chemical structures of molecules." @default.
• W2092203867 created "2016-06-24" @default.
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• W2092203867 creator A5041762507 @default.
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• W2092203867 date "2010-10-01" @default.
• W2092203867 modified "2023-10-17" @default.
• W2092203867 title "Dual action of a dinoflagellate-derived precursor of Pacific ciguatoxins (P-CTX-4B) on voltage-dependent K+ and Na+ channels of single myelinated axons" @default.
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• W2092203867 doi "https://doi.org/10.1016/j.toxicon.2009.06.035" @default.
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