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- W2092204044 endingPage "47" @default.
- W2092204044 startingPage "33" @default.
- W2092204044 abstract "The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family consists of 19 proteases. These enzymes are known to play important roles in development, angiogenesis and coagulation; dysregulation and mutation of these enzymes have been implicated in many disease processes, such as inflammation, cancer, arthritis and atherosclerosis. This review briefly summarizes the structural organization and functional roles of ADAMTSs in normal and pathological conditions, focusing on members that are known to be involved in the degradation of extracellular matrix and loss of cartilage in arthritis, including the aggrecanases (ADAMTS-4 and ADAMTS-5), ADAMTS-7 and ADAMTS-12, the latter two are associated with cartilage oligomeric matrix protein (COMP), a component of the cartilage extracellular matrix (ECM). We will discuss the expression pattern and the regulation of these metalloproteinases at multiple levels, including their interaction with substrates, induction by pro-inflammatory cytokines, protein processing, inhibition (e.g., TIMP-3, alpha-2-macroglobulin, GEP), and activation (e.g., syndecan-4, PACE-4)." @default.
- W2092204044 created "2016-06-24" @default.
- W2092204044 creator A5016995949 @default.
- W2092204044 creator A5039402267 @default.
- W2092204044 date "2010-01-01" @default.
- W2092204044 modified "2023-10-08" @default.
- W2092204044 title "The role of ADAMTSs in arthritis" @default.
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