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- W2092206243 abstract "The kinetochore is the crucial apparatus regulating chromosome segregation in mitosis and meiosis. Particularly in meiosis I, unlike in mitosis, sister kinetochores are captured by microtubules emanating from the same spindle pole (mono-orientation) and centromeric cohesion mediated by cohesin is protected in the following anaphase. Although meiotic kinetochore factors have been identified only in budding and fission yeasts, these molecules and their functions are thought to have diverged earlier. Therefore, a conserved mechanism for meiotic kinetochore regulation remains elusive. Here we have identified in mouse a meiosis-specific kinetochore factor that we termed MEIKIN, which functions in meiosis I but not in meiosis II or mitosis. MEIKIN plays a crucial role in both mono-orientation and centromeric cohesion protection, partly by stabilizing the localization of the cohesin protector shugoshin. These functions are mediated mainly by the activity of Polo-like kinase PLK1, which is enriched to kinetochores in a MEIKIN-dependent manner. Our integrative analysis indicates that the long-awaited key regulator of meiotic kinetochore function is Meikin, which is conserved from yeasts to humans. The long elusive mammalian meiosis-specific kinetochore factor has been identified in mice; MEIKIN—which plays an equivalent role to the yeast proteins Spo13 and Moa1—ensures mono-orientation, protects sister chromatid cohesion and recruits the kinase PLK1 to the kinetochores. During the first of the meiotic cell divisions that generate germ cells, sister kinetochores are captured by microtubules from the same spindle pole so that sister chromatids can be segregated into the same daughter cell. Yoshinori Watanabe and colleagues have now identified MEIKIN as the long-sought-after meiosis-specific kinetochore factor that ensures mono-orientation and protects sister chromatid cohesion during the first meiotic division in mouse germ cells. It functions mainly by recruiting the kinase PLK1 to kinetochores. Previously identified budding and fission yeast proteins, Spo13 and Moa1, respectively, are shown to be functional homologues of MEIKIN, and the authors propose that together they form the 'Meikin' family of meiosis-I-specific kinetochore factors." @default.
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- W2092206243 date "2014-12-24" @default.
- W2092206243 modified "2023-10-05" @default.
- W2092206243 title "Meikin is a conserved regulator of meiosis-I-specific kinetochore function" @default.
- W2092206243 cites W1509135035 @default.
- W2092206243 cites W1529934215 @default.
- W2092206243 cites W1638194466 @default.
- W2092206243 cites W1939066949 @default.
- W2092206243 cites W1965308596 @default.
- W2092206243 cites W1967096927 @default.
- W2092206243 cites W1970597357 @default.
- W2092206243 cites W1971801697 @default.
- W2092206243 cites W1972204893 @default.
- W2092206243 cites W1983077985 @default.
- W2092206243 cites W1983712701 @default.
- W2092206243 cites W1984895636 @default.
- W2092206243 cites W1990265320 @default.
- W2092206243 cites W1990850819 @default.
- W2092206243 cites W1993079403 @default.
- W2092206243 cites W1999849989 @default.
- W2092206243 cites W2005654623 @default.
- W2092206243 cites W2010699331 @default.
- W2092206243 cites W2025128415 @default.
- W2092206243 cites W2028355074 @default.
- W2092206243 cites W2031847595 @default.
- W2092206243 cites W2035114192 @default.
- W2092206243 cites W2042871902 @default.
- W2092206243 cites W2043846400 @default.
- W2092206243 cites W2048551141 @default.
- W2092206243 cites W2051502996 @default.
- W2092206243 cites W2056322543 @default.
- W2092206243 cites W2058727957 @default.
- W2092206243 cites W2059069459 @default.
- W2092206243 cites W2064363195 @default.
- W2092206243 cites W2067027588 @default.
- W2092206243 cites W2072306817 @default.
- W2092206243 cites W2076443479 @default.
- W2092206243 cites W2078743927 @default.
- W2092206243 cites W2079274504 @default.
- W2092206243 cites W2079321797 @default.
- W2092206243 cites W2080831216 @default.
- W2092206243 cites W2082221116 @default.
- W2092206243 cites W2084134136 @default.
- W2092206243 cites W2086575042 @default.
- W2092206243 cites W2095769598 @default.
- W2092206243 cites W2099544293 @default.
- W2092206243 cites W2105932869 @default.
- W2092206243 cites W2110691960 @default.
- W2092206243 cites W2114510559 @default.
- W2092206243 cites W2116282691 @default.
- W2092206243 cites W2116838769 @default.
- W2092206243 cites W2118741003 @default.
- W2092206243 cites W2120439612 @default.
- W2092206243 cites W2120785595 @default.
- W2092206243 cites W2126460280 @default.
- W2092206243 cites W2128923695 @default.
- W2092206243 cites W2144113763 @default.
- W2092206243 cites W2144228190 @default.
- W2092206243 cites W2144994329 @default.
- W2092206243 cites W2154967210 @default.
- W2092206243 cites W2156216715 @default.
- W2092206243 cites W2157077875 @default.
- W2092206243 cites W2168405417 @default.
- W2092206243 cites W2203076878 @default.
- W2092206243 cites W2396949742 @default.
- W2092206243 doi "https://doi.org/10.1038/nature14097" @default.
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