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- W2092208329 abstract "The effect of breathing through inspiratory flow resistive loads ranging between 4.5 and 27.0 cm H2O/L/s was assessed in eight patients with amyotrophic lateral sclerosis (ALS) and in eight control subjects. ALS patients developed respiratory muscle fatigue manifested by significant declines in negative inspiratory pressure (18.3%), vital capacity (7.2%), and peak inspiratory flow rate (5.5%). Control subjects did not fatigue with these resistances. In ALS patients, theophylline increased respiratory muscle strength after resistive breathing as manifested by an increase in negative inspiratory pressure (28.2%), vital capacity (10%), and peak inspiratory flow rate (11.8%). It is concluded that in patients with ALS, the already weakened respiratory muscles are easily fatigued. Furthermore, theophylline can strengthen loaded respiratory muscles in patients with ALS." @default.
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- W2092208329 date "1989-06-01" @default.
- W2092208329 modified "2023-09-25" @default.
- W2092208329 title "Effect of Inspiratory Resistance and Theophylline on Respiratory Muscle Strength in Patients with Amyotrophic Lateral Sclerosis" @default.
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- W2092208329 doi "https://doi.org/10.1164/ajrccm/139.6.1418" @default.
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