FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092213784> ?p ?o ?g. }

• W2092213784 endingPage "193" @default.
• W2092213784 startingPage "187" @default.
• W2092213784 abstract "Sequence polymorphisms in enzymes involved in drug metabolism have been widely implicated in the differences observed in the sensitivity to various xenobiotics. The flavin-containing monooxygenase (FMO) gene family in humans catalyzes the monooxygenation of numerous N-, P- and S-containing drugs, pesticides, and environmental toxicants. Six genes (FMO1-6) have been identified so far, but the major alleles of FMO2 and FMO6 encode nonfunctional proteins due to a nonsense mutation and splice-site abnormalities, respectively. Data on structural variants exist for human FMO2 and 3, whereas very little is known about the other FMO genes. FMO1-6 were scanned in 50 individuals of African-American descent using the method, detection of virtually all mutations-single-strand conformational polymorphism. A total of 49 sequence variants were identified in a total 1.35 megabases of scanned sequence, of which 29 were variants affecting protein structure or expression. Some of these are expected to affect the activity of the protein, including a nonsense mutation in FMO1 (R502X) and missense mutations in FMO1 (I303T), FMO4 (E339Q), and FMO5 (P457L) that occur in highly conserved amino acids. Additional deleterious substitutions in FMO2 (del337G) and FMO6 (Q105X) were also identified. Multiple structural variants in the FMO gene family were observed in this African-American sample. Some of the substitutions identified in this study might be useful markers in future association studies assessing sensitivity to environmental toxicants and common disease." @default.
• W2092213784 created "2016-06-24" @default.
• W2092213784 creator A5015219753 @default.
• W2092213784 creator A5058921323 @default.
• W2092213784 creator A5063106224 @default.
• W2092213784 creator A5083962248 @default.
• W2092213784 date "2003-02-01" @default.
• W2092213784 modified "2023-10-12" @default.
• W2092213784 title "Identification of Novel Variants of the Flavin-Containing Monooxygenase Gene Family in African Americans" @default.
• W2092213784 cites W1518683637 @default.
• W2092213784 cites W1766115599 @default.
• W2092213784 cites W1963516367 @default.
• W2092213784 cites W1971651706 @default.
• W2092213784 cites W1977924630 @default.
• W2092213784 cites W1986637631 @default.
• W2092213784 cites W1987941468 @default.
• W2092213784 cites W2010547715 @default.
• W2092213784 cites W2021938166 @default.
• W2092213784 cites W2023769846 @default.
• W2092213784 cites W2024582151 @default.
• W2092213784 cites W2037424123 @default.
• W2092213784 cites W2040653665 @default.
• W2092213784 cites W2048048104 @default.
• W2092213784 cites W2053206318 @default.
• W2092213784 cites W2054100515 @default.
• W2092213784 cites W2055666951 @default.
• W2092213784 cites W2059515258 @default.
• W2092213784 cites W2063353051 @default.
• W2092213784 cites W2065359722 @default.
• W2092213784 cites W2068390361 @default.
• W2092213784 cites W2069400768 @default.
• W2092213784 cites W2076617730 @default.
• W2092213784 cites W2081056949 @default.
• W2092213784 cites W2087820100 @default.
• W2092213784 cites W2088404366 @default.
• W2092213784 cites W2093996636 @default.
• W2092213784 cites W2099381267 @default.
• W2092213784 cites W2111899360 @default.
• W2092213784 cites W2113034203 @default.
• W2092213784 cites W2120152160 @default.
• W2092213784 cites W2151877060 @default.
• W2092213784 cites W36301068 @default.
• W2092213784 cites W4254959849 @default.
• W2092213784 cites W4323517737 @default.
• W2092213784 cites W4366763327 @default.
• W2092213784 doi "https://doi.org/10.1124/dmd.31.2.187" @default.
• W2092213784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12527699" @default.
• W2092213784 hasPublicationYear "2003" @default.
• W2092213784 type Work @default.
• W2092213784 sameAs 2092213784 @default.
• W2092213784 citedByCount "65" @default.
• W2092213784 countsByYear W20922137842012 @default.
• W2092213784 countsByYear W20922137842013 @default.
• W2092213784 countsByYear W20922137842014 @default.
• W2092213784 countsByYear W20922137842015 @default.
• W2092213784 countsByYear W20922137842016 @default.
• W2092213784 countsByYear W20922137842017 @default.
• W2092213784 countsByYear W20922137842018 @default.
• W2092213784 countsByYear W20922137842019 @default.
• W2092213784 countsByYear W20922137842020 @default.
• W2092213784 countsByYear W20922137842021 @default.
• W2092213784 countsByYear W20922137842022 @default.
• W2092213784 crossrefType "journal-article" @default.
• W2092213784 hasAuthorship W2092213784A5015219753 @default.
• W2092213784 hasAuthorship W2092213784A5058921323 @default.
• W2092213784 hasAuthorship W2092213784A5063106224 @default.
• W2092213784 hasAuthorship W2092213784A5083962248 @default.
• W2092213784 hasConcept C104317684 @default.
• W2092213784 hasConcept C13002179 @default.
• W2092213784 hasConcept C143065580 @default.
• W2092213784 hasConcept C181199279 @default.
• W2092213784 hasConcept C2776146729 @default.
• W2092213784 hasConcept C501734568 @default.
• W2092213784 hasConcept C526171541 @default.
• W2092213784 hasConcept C54355233 @default.
• W2092213784 hasConcept C55493867 @default.
• W2092213784 hasConcept C62923972 @default.
• W2092213784 hasConcept C75563809 @default.
• W2092213784 hasConcept C86803240 @default.
• W2092213784 hasConcept C96777560 @default.
• W2092213784 hasConceptScore W2092213784C104317684 @default.
• W2092213784 hasConceptScore W2092213784C13002179 @default.
• W2092213784 hasConceptScore W2092213784C143065580 @default.
• W2092213784 hasConceptScore W2092213784C181199279 @default.
• W2092213784 hasConceptScore W2092213784C2776146729 @default.
• W2092213784 hasConceptScore W2092213784C501734568 @default.
• W2092213784 hasConceptScore W2092213784C526171541 @default.
• W2092213784 hasConceptScore W2092213784C54355233 @default.
• W2092213784 hasConceptScore W2092213784C55493867 @default.
• W2092213784 hasConceptScore W2092213784C62923972 @default.
• W2092213784 hasConceptScore W2092213784C75563809 @default.
• W2092213784 hasConceptScore W2092213784C86803240 @default.
• W2092213784 hasConceptScore W2092213784C96777560 @default.
• W2092213784 hasIssue "2" @default.
• W2092213784 hasLocation W20922137841 @default.
• W2092213784 hasLocation W20922137842 @default.
• W2092213784 hasOpenAccess W2092213784 @default.
• W2092213784 hasPrimaryLocation W20922137841 @default.

• next