Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092230890> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2092230890 endingPage "763" @default.
- W2092230890 startingPage "759" @default.
- W2092230890 abstract "The physiologic activities concerned with hemostasis and associated with the Factor VIII macromolecular complex were investigated in swine with von Willebrand's disease after infusion of cryoprecipitate, a lyophilized Factor VIII concentrate, or porcine serum. Immediately after each infusion the various activities antihemophilic factor, von Willebrand platelet aggregating factor, and Factor VIII-related antigen, were elevated in approximate proportion to dose and the bleeding time was shortened.There was a late secondary rise in antihemophilic factor. During the period after infusion, there was a differential fall-off of the various activities, with the bleeding time effect lost first, followed by the von Willebrand platelet aggregating factor and then by the Factor VIII-related antigen. The plasma from swine with von Willebrand's disease late after infusion contained high levels of antihemophilic factor without other detectable activities of the complex. Antihemophilic factor, free of the other components, obtained from plasma from swine with von Willebrand's disease either before or late after infusion eluted from agarose gel columns both as high and lower molecular weight material, unlike normal antihemophilic factor, which had a high molecular weight. In contrast, on ultracentrifugation the antihemophilic factor in these plasma sedimented slowly, even though chromatographically the plasmas contained both high and low molecular weight factor. All of the Factor VIII complex activities in normal porcine plasma sedimented rapidly. These studies demonstrate the heterogeneity of the Factor VIII complex and the apparent dependence of its chromatographic and sedimentation behavior on the functional activities associated with the complex." @default.
- W2092230890 created "2016-06-24" @default.
- W2092230890 creator A5012971484 @default.
- W2092230890 creator A5013346421 @default.
- W2092230890 creator A5041600536 @default.
- W2092230890 creator A5069960350 @default.
- W2092230890 creator A5075437070 @default.
- W2092230890 date "1977-02-01" @default.
- W2092230890 modified "2023-09-26" @default.
- W2092230890 title "Macromolecular factor VIII complex: functional and structural heterogeneity observed in von Willebrand swine with transfusion." @default.
- W2092230890 cites W101550465 @default.
- W2092230890 cites W110617401 @default.
- W2092230890 cites W1996208225 @default.
- W2092230890 cites W2004391558 @default.
- W2092230890 cites W2018065121 @default.
- W2092230890 cites W2030558865 @default.
- W2092230890 cites W2057487614 @default.
- W2092230890 cites W2060713652 @default.
- W2092230890 cites W2062595903 @default.
- W2092230890 cites W2083354180 @default.
- W2092230890 cites W2087992035 @default.
- W2092230890 cites W2138762884 @default.
- W2092230890 cites W2158841112 @default.
- W2092230890 cites W2345473432 @default.
- W2092230890 cites W2412079422 @default.
- W2092230890 cites W2417876606 @default.
- W2092230890 cites W2438842611 @default.
- W2092230890 cites W57326289 @default.
- W2092230890 doi "https://doi.org/10.1073/pnas.74.2.759" @default.
- W2092230890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/392373" @default.
- W2092230890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/300481" @default.
- W2092230890 hasPublicationYear "1977" @default.
- W2092230890 type Work @default.
- W2092230890 sameAs 2092230890 @default.
- W2092230890 citedByCount "15" @default.
- W2092230890 countsByYear W20922308902015 @default.
- W2092230890 countsByYear W20922308902017 @default.
- W2092230890 crossrefType "journal-article" @default.
- W2092230890 hasAuthorship W2092230890A5012971484 @default.
- W2092230890 hasAuthorship W2092230890A5013346421 @default.
- W2092230890 hasAuthorship W2092230890A5041600536 @default.
- W2092230890 hasAuthorship W2092230890A5069960350 @default.
- W2092230890 hasAuthorship W2092230890A5075437070 @default.
- W2092230890 hasBestOaLocation W20922308902 @default.
- W2092230890 hasConcept C126322002 @default.
- W2092230890 hasConcept C134018914 @default.
- W2092230890 hasConcept C185592680 @default.
- W2092230890 hasConcept C2778258694 @default.
- W2092230890 hasConcept C2778382381 @default.
- W2092230890 hasConcept C2778589496 @default.
- W2092230890 hasConcept C2778780528 @default.
- W2092230890 hasConcept C2779394231 @default.
- W2092230890 hasConcept C2781221834 @default.
- W2092230890 hasConcept C54689828 @default.
- W2092230890 hasConcept C55493867 @default.
- W2092230890 hasConcept C71924100 @default.
- W2092230890 hasConcept C89560881 @default.
- W2092230890 hasConceptScore W2092230890C126322002 @default.
- W2092230890 hasConceptScore W2092230890C134018914 @default.
- W2092230890 hasConceptScore W2092230890C185592680 @default.
- W2092230890 hasConceptScore W2092230890C2778258694 @default.
- W2092230890 hasConceptScore W2092230890C2778382381 @default.
- W2092230890 hasConceptScore W2092230890C2778589496 @default.
- W2092230890 hasConceptScore W2092230890C2778780528 @default.
- W2092230890 hasConceptScore W2092230890C2779394231 @default.
- W2092230890 hasConceptScore W2092230890C2781221834 @default.
- W2092230890 hasConceptScore W2092230890C54689828 @default.
- W2092230890 hasConceptScore W2092230890C55493867 @default.
- W2092230890 hasConceptScore W2092230890C71924100 @default.
- W2092230890 hasConceptScore W2092230890C89560881 @default.
- W2092230890 hasIssue "2" @default.
- W2092230890 hasLocation W20922308901 @default.
- W2092230890 hasLocation W20922308902 @default.
- W2092230890 hasLocation W20922308903 @default.
- W2092230890 hasOpenAccess W2092230890 @default.
- W2092230890 hasPrimaryLocation W20922308901 @default.
- W2092230890 hasRelatedWork W1573631883 @default.
- W2092230890 hasRelatedWork W1972495894 @default.
- W2092230890 hasRelatedWork W1988467776 @default.
- W2092230890 hasRelatedWork W2008104329 @default.
- W2092230890 hasRelatedWork W2092230890 @default.
- W2092230890 hasRelatedWork W2095386883 @default.
- W2092230890 hasRelatedWork W4238470110 @default.
- W2092230890 hasRelatedWork W76823258 @default.
- W2092230890 hasRelatedWork W13646949 @default.
- W2092230890 hasRelatedWork W2405169275 @default.
- W2092230890 hasVolume "74" @default.
- W2092230890 isParatext "false" @default.
- W2092230890 isRetracted "false" @default.
- W2092230890 magId "2092230890" @default.
- W2092230890 workType "article" @default.