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- W2092234576 abstract "The actions of thyroxine, 5α-dihydrotestosterone and hydrocortisone singly or in combination in enzyme regulation in the submandibular gland were studied in intact and adrenalectomized female mice. 1. Adrenalectomy decreased the activity of trypsin-like esteroprotease (EC 3.4.4.-), and administration of hydrocortisone to adrenalectomized mice restored the activity to normal. 2. Hydrocortisone and thyroxine had synergistic effects in induction of esteroprotease in adrenalectomized mice, but 5α-dihydrotestosterone and hydrocortisone did not have synergistic effects in either intact or adrenalectomized mice. 3. The activity of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) was not influenced by change in the glucocorticoid level, but was increased by thyroxine and 5α-dihydrotestosterone in both adrenalectomized mice and intact mice. 4. Isoelectric focusing in polyacrylamide gel showed that there are three distinct activities of esteroprotease in this gland with isoelectric points of 5.6, 6.2 and 7.3. Both thyroxine and 5α-dihydrotestosterone similarly induced these activities and glucocorticoids did not affect the isozyme patterns induced by the other two hormones." @default.
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- W2092234576 date "1979-04-01" @default.
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- W2092234576 title "Synergistic effects of thyroxine and glucocorticoid in induction of trypsin-like esteroprotease in mouse submandibular gland" @default.
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- W2092234576 doi "https://doi.org/10.1016/0304-4165(79)90234-4" @default.
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