Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092236356> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2092236356 endingPage "1082" @default.
- W2092236356 startingPage "1077" @default.
- W2092236356 abstract "In this study, we have developed Proteasix, an open-source peptide-centric tool that can be used to predict in silico the proteases involved in naturally occurring peptide generation. We developed a curated cleavage site (CS) database, containing 3500 entries about human protease/CS combinations. On top of this database, we built a tool, Proteasix, which allows CS retrieval and protease associations from a list of peptides. To establish the proof of concept of the approach, we used a list of 1388 peptides identified from human urine samples, and compared the prediction to the analysis of 1003 randomly generated amino acid sequences. Metalloprotease activity was predominantly involved in urinary peptide generation, and more particularly to peptides associated with extracellular matrix remodelling, compared to proteins from other origins. In comparison, random sequences returned almost no results, highlighting the specificity of the prediction. This study provides a tool that can facilitate linking of identified protein fragments to predicted protease activity, and therefore into presumed mechanisms of disease. Experiments are needed to confirm the in silico hypotheses; nevertheless, this approach may be of great help to better understand molecular mechanisms of disease, and define new biomarkers, and therapeutic targets." @default.
- W2092236356 created "2016-06-24" @default.
- W2092236356 creator A5007256930 @default.
- W2092236356 creator A5024391183 @default.
- W2092236356 creator A5045393131 @default.
- W2092236356 creator A5049799218 @default.
- W2092236356 creator A5052560289 @default.
- W2092236356 creator A5090197441 @default.
- W2092236356 date "2013-02-26" @default.
- W2092236356 modified "2023-10-06" @default.
- W2092236356 title "Proteasix: A tool for automated and large-scale prediction of proteases involved in naturally occurring peptide generation" @default.
- W2092236356 cites W1975278814 @default.
- W2092236356 cites W1976731666 @default.
- W2092236356 cites W1987937826 @default.
- W2092236356 cites W1995283805 @default.
- W2092236356 cites W2002263377 @default.
- W2092236356 cites W2008197152 @default.
- W2092236356 cites W2009393104 @default.
- W2092236356 cites W2021790913 @default.
- W2092236356 cites W2075503331 @default.
- W2092236356 cites W2078134389 @default.
- W2092236356 cites W2078795022 @default.
- W2092236356 cites W2084975981 @default.
- W2092236356 cites W2102225353 @default.
- W2092236356 cites W2111973517 @default.
- W2092236356 cites W2113309273 @default.
- W2092236356 cites W2117925356 @default.
- W2092236356 cites W2122460814 @default.
- W2092236356 cites W2122825204 @default.
- W2092236356 cites W2160664288 @default.
- W2092236356 doi "https://doi.org/10.1002/pmic.201200493" @default.
- W2092236356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23348921" @default.
- W2092236356 hasPublicationYear "2013" @default.
- W2092236356 type Work @default.
- W2092236356 sameAs 2092236356 @default.
- W2092236356 citedByCount "101" @default.
- W2092236356 countsByYear W20922363562013 @default.
- W2092236356 countsByYear W20922363562014 @default.
- W2092236356 countsByYear W20922363562015 @default.
- W2092236356 countsByYear W20922363562016 @default.
- W2092236356 countsByYear W20922363562017 @default.
- W2092236356 countsByYear W20922363562018 @default.
- W2092236356 countsByYear W20922363562019 @default.
- W2092236356 countsByYear W20922363562020 @default.
- W2092236356 countsByYear W20922363562021 @default.
- W2092236356 countsByYear W20922363562022 @default.
- W2092236356 countsByYear W20922363562023 @default.
- W2092236356 crossrefType "journal-article" @default.
- W2092236356 hasAuthorship W2092236356A5007256930 @default.
- W2092236356 hasAuthorship W2092236356A5024391183 @default.
- W2092236356 hasAuthorship W2092236356A5045393131 @default.
- W2092236356 hasAuthorship W2092236356A5049799218 @default.
- W2092236356 hasAuthorship W2092236356A5052560289 @default.
- W2092236356 hasAuthorship W2092236356A5090197441 @default.
- W2092236356 hasConcept C104317684 @default.
- W2092236356 hasConcept C181199279 @default.
- W2092236356 hasConcept C182220744 @default.
- W2092236356 hasConcept C2775905019 @default.
- W2092236356 hasConcept C2776714187 @default.
- W2092236356 hasConcept C2779281246 @default.
- W2092236356 hasConcept C41008148 @default.
- W2092236356 hasConcept C55493867 @default.
- W2092236356 hasConcept C60644358 @default.
- W2092236356 hasConcept C70721500 @default.
- W2092236356 hasConcept C77088390 @default.
- W2092236356 hasConcept C86803240 @default.
- W2092236356 hasConceptScore W2092236356C104317684 @default.
- W2092236356 hasConceptScore W2092236356C181199279 @default.
- W2092236356 hasConceptScore W2092236356C182220744 @default.
- W2092236356 hasConceptScore W2092236356C2775905019 @default.
- W2092236356 hasConceptScore W2092236356C2776714187 @default.
- W2092236356 hasConceptScore W2092236356C2779281246 @default.
- W2092236356 hasConceptScore W2092236356C41008148 @default.
- W2092236356 hasConceptScore W2092236356C55493867 @default.
- W2092236356 hasConceptScore W2092236356C60644358 @default.
- W2092236356 hasConceptScore W2092236356C70721500 @default.
- W2092236356 hasConceptScore W2092236356C77088390 @default.
- W2092236356 hasConceptScore W2092236356C86803240 @default.
- W2092236356 hasIssue "7" @default.
- W2092236356 hasLocation W20922363561 @default.
- W2092236356 hasLocation W20922363562 @default.
- W2092236356 hasOpenAccess W2092236356 @default.
- W2092236356 hasPrimaryLocation W20922363561 @default.
- W2092236356 hasRelatedWork W1004757146 @default.
- W2092236356 hasRelatedWork W2066420944 @default.
- W2092236356 hasRelatedWork W2072272548 @default.
- W2092236356 hasRelatedWork W2086937831 @default.
- W2092236356 hasRelatedWork W2092236356 @default.
- W2092236356 hasRelatedWork W2219318606 @default.
- W2092236356 hasRelatedWork W2378962048 @default.
- W2092236356 hasRelatedWork W2491451478 @default.
- W2092236356 hasRelatedWork W2595794961 @default.
- W2092236356 hasRelatedWork W4205874200 @default.
- W2092236356 hasVolume "13" @default.
- W2092236356 isParatext "false" @default.
- W2092236356 isRetracted "false" @default.
- W2092236356 magId "2092236356" @default.
- W2092236356 workType "article" @default.