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- W2092240515 endingPage "231" @default.
- W2092240515 startingPage "222" @default.
- W2092240515 abstract "The accumulation of interstitial matrix represents the final common pathway of most forms of kidney disease. Much of this matrix is synthesized by interstitial myofibroblasts, recruited from resident fibroblasts and circulating precursors. In addition, a significant proportion is derived from epithelial-mesenchymal transition (EMT) of tubuloepithelial cells. The importance of EMT has been demonstrated in experimental models, where blockade of EMT attenuates renal fibrosis. Although a number of factors may initiate EMT in the kidney, the most potent is transforming growth factor-β1 (TGF-β1). Moreover, many other prosclerotic factors have effects on EMT indirectly, via induction of TGF-β1. Signaling events in this pathway include activation of Smad/integrin-linked kinase (ILK) and connective tissue growth factor (CTGF). Basement membrane integrity is also a key regulator of EMT. In particular, overexpression of matrix metalloproteinase-2 has a key role in the initiation of EMT, membrane dissolution, and the interstitial transit of transformed mesenchymal cells. Endogenous inhibitors of EMT also play an important counterregulatory role both to prevent EMT and stimulate uncommitted cells to regain their tubular phenotype (mesenchymal-epithelial transition). Such inhibitors represent a potential therapeutic approach, offering a mechanism to slow or even redress established renal fibrosis." @default.
- W2092240515 created "2016-06-24" @default.
- W2092240515 creator A5008098216 @default.
- W2092240515 creator A5045578819 @default.
- W2092240515 creator A5079626755 @default.
- W2092240515 date "2007-01-01" @default.
- W2092240515 modified "2023-09-26" @default.
- W2092240515 title "The Role of Tubular Epithelial-Mesenchymal Transition in Progressive Kidney Disease" @default.
- W2092240515 cites W1557028690 @default.
- W2092240515 cites W1566750909 @default.
- W2092240515 cites W1636022999 @default.
- W2092240515 cites W1932132006 @default.
- W2092240515 cites W1964177773 @default.
- W2092240515 cites W1971754929 @default.
- W2092240515 cites W1972534313 @default.
- W2092240515 cites W1973079688 @default.
- W2092240515 cites W1974926454 @default.
- W2092240515 cites W1975953243 @default.
- W2092240515 cites W1982010552 @default.
- W2092240515 cites W1982125065 @default.
- W2092240515 cites W1982154515 @default.
- W2092240515 cites W1982670131 @default.
- W2092240515 cites W1982999513 @default.
- W2092240515 cites W1985301994 @default.
- W2092240515 cites W1989159761 @default.
- W2092240515 cites W1993345123 @default.
- W2092240515 cites W1993645457 @default.
- W2092240515 cites W1996995584 @default.
- W2092240515 cites W2009407308 @default.
- W2092240515 cites W2030750844 @default.
- W2092240515 cites W2032942532 @default.
- W2092240515 cites W2036044995 @default.
- W2092240515 cites W2042606264 @default.
- W2092240515 cites W2046383629 @default.
- W2092240515 cites W2046401692 @default.
- W2092240515 cites W205288085 @default.
- W2092240515 cites W2054282870 @default.
- W2092240515 cites W2055888888 @default.
- W2092240515 cites W2059128799 @default.
- W2092240515 cites W2059946538 @default.
- W2092240515 cites W2059988766 @default.
- W2092240515 cites W2061849818 @default.
- W2092240515 cites W2062268212 @default.
- W2092240515 cites W2062273929 @default.
- W2092240515 cites W2064438537 @default.
- W2092240515 cites W2066899114 @default.
- W2092240515 cites W2069525354 @default.
- W2092240515 cites W2071349049 @default.
- W2092240515 cites W2077462602 @default.
- W2092240515 cites W2080627387 @default.
- W2092240515 cites W2083667760 @default.
- W2092240515 cites W2083908324 @default.
- W2092240515 cites W2087027548 @default.
- W2092240515 cites W2097887036 @default.
- W2092240515 cites W2101051256 @default.
- W2092240515 cites W2101417810 @default.
- W2092240515 cites W2101446591 @default.
- W2092240515 cites W2102319255 @default.
- W2092240515 cites W2105449265 @default.
- W2092240515 cites W2106887481 @default.
- W2092240515 cites W2107034917 @default.
- W2092240515 cites W2111731443 @default.
- W2092240515 cites W2113638068 @default.
- W2092240515 cites W2114752142 @default.
- W2092240515 cites W2116053081 @default.
- W2092240515 cites W2118650242 @default.
- W2092240515 cites W2122261044 @default.
- W2092240515 cites W2124598461 @default.
- W2092240515 cites W2125486836 @default.
- W2092240515 cites W2126439225 @default.
- W2092240515 cites W2127801795 @default.
- W2092240515 cites W2132803823 @default.
- W2092240515 cites W2133193835 @default.
- W2092240515 cites W2134891317 @default.
- W2092240515 cites W2135664105 @default.
- W2092240515 cites W2137759284 @default.
- W2092240515 cites W2138760138 @default.
- W2092240515 cites W2142278869 @default.
- W2092240515 cites W2146232095 @default.
- W2092240515 cites W2146350838 @default.
- W2092240515 cites W2147068335 @default.
- W2092240515 cites W2148184356 @default.
- W2092240515 cites W2149271063 @default.
- W2092240515 cites W2154973691 @default.
- W2092240515 cites W2158078054 @default.
- W2092240515 cites W2158599500 @default.
- W2092240515 cites W2159526033 @default.
- W2092240515 cites W2159932011 @default.
- W2092240515 cites W2160382989 @default.
- W2092240515 cites W2164140241 @default.
- W2092240515 cites W2168918540 @default.
- W2092240515 cites W2170933176 @default.
- W2092240515 cites W2290010678 @default.
- W2092240515 cites W2317298663 @default.
- W2092240515 cites W2460444072 @default.
- W2092240515 cites W2004252049 @default.
- W2092240515 doi "https://doi.org/10.1159/000101323" @default.
- W2092240515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17587828" @default.