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• W2092241100 endingPage "535" @default.
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• W2092241100 abstract "Objectives We tested the hypothesis that a common functional variant in brain‐derived neurotrophic factor ( BDNF ), Val66Met, which has been shown to be associated with increased body mass index ( BMI ) in schizophrenia ( SCZ ) and schizoaffective disorder ( SAD ), is also associated with antipsychotic‐induced weight gain in bipolar disorder ( BPD ). Association of Val66Met with other metabolic measures, including high‐ and low‐density cholesterol, triglycerides, total cholesterol, fasting blood glucose, and hemoglobin A1c, was also tested. Methods This was a 12‐month, prospective, randomized trial of two atypical antipsychotic drugs ( APD s) with moderate (risperidone) or high (olanzapine) risk to cause weight gain. Subjects were diagnosed as having BPD (n = 90) and SCZ or SAD (n = 76). Results BMI was significantly greater in all diagnoses for Met66 allele carriers at six months (p = 0.01). Met66 carriers with BPD showed a greater increase in the triglycerides/high‐density ( HDL ) cholesterol ratio (p = 0.01), a key marker for metabolic syndrome related to insulin resistance, and log‐triglycerides (p = 0.04), after three or six months of treatment. Met66 carriers had the greatest increase in log‐triglycerides (p = 0.03) and triglycerides/ HDL cholesterol ratio after three months of treatment with risperidone (p = 0.003), and the highest BMI at six months (p = 0.01). Conclusions The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well." @default.
• W2092241100 created "2016-06-24" @default.
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• W2092241100 date "2015-04-15" @default.
• W2092241100 modified "2023-10-05" @default.
• W2092241100 title "The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia" @default.
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• W2092241100 doi "https://doi.org/10.1111/bdi.12294" @default.
• W2092241100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25874530" @default.
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