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• W2092241437 abstract "Endothelin, one of the most potent vasoconstrictor known, has been suggested to act as an endogenous agonist of L-type Ca2+ channels. In this paper we show that endothelin stimulates the metabolism of inositol phosphates and induces the mobilization of intracellular Ca2+ stores. The transient activation of Ca2+-sensitive K+ channel provokes an hyperpolarization of the membrane. It is followed by a sustained depolarization which is due to the opening of a non-specific cation channel which is permeable to Ca2+ and Mg2+. The depolarization then activates L-type Ca2+ channels. This mechanism of action explains why part of the endothelin-induced vasocontriction is eliminated by L-type Ca2+ channel blockers." @default.
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• W2092241437 date "1988-12-01" @default.
• W2092241437 modified "2023-09-25" @default.
• W2092241437 title "Molecular mechanism of action of the vasoconstrictor peptide endothelin" @default.
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• W2092241437 doi "https://doi.org/10.1016/s0006-291x(88)80970-7" @default.
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