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• W2092241477 abstract "The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb, brain, and gonadal development. In the Drosophila eye, dac is a key component of the Retinal Determination Gene Network (RDGN) governing the normal initiation of the morphogenetic furrow and thereby eye development. Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate and ovarian cancer. The molecular mechanisms by which DACH1 regulates differentiation and tumorigenesis are discussed herein. The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb, brain, and gonadal development. In the Drosophila eye, dac is a key component of the Retinal Determination Gene Network (RDGN) governing the normal initiation of the morphogenetic furrow and thereby eye development. Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate and ovarian cancer. The molecular mechanisms by which DACH1 regulates differentiation and tumorigenesis are discussed herein." @default.
• W2092241477 created "2016-06-24" @default.
• W2092241477 creator A5005183715 @default.
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• W2092241477 date "2010-01-01" @default.
• W2092241477 modified "2023-10-16" @default.
• W2092241477 title "The Dachshund gene in development and hormone-responsive tumorigenesis" @default.
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• W2092241477 doi "https://doi.org/10.1016/j.tem.2009.08.002" @default.
• W2092241477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2818438" @default.
• W2092241477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19896866" @default.
• W2092241477 hasPublicationYear "2010" @default.
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