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- W2092242559 abstract "Cachexia involves the loss of skeletal muscle and adipose tissue and can occur in conjunction with many cancers, leading to an increased mortality risk. Often investigated mechanisms inducing cachectic muscle loss include increased protein degradation, protein synthesis suppression, and more recently myonuclear apoptosis. Our laboratory has published that the ApcMin/+ mouse, which develops intestinal tumors, undergoes cachexia. PURPOSE: The purpose of this study was to determine if elevated apoptosis was associated with muscle mass loss in cachectic ApcMin/+ mice. METHODS: The expression of Bax, a pro-apoptotic protein, was used as an indicator of apoptosis and quantified by Western blot in gastrocnemius muscles from ApcMin/+ mice stratified by degree of cachexia (mild/non-cachectic, moderate, or severe). RESULTS: Gastrocnemius muscle mass decreased 61% in severely cachectic mice (52 ± 5 mg; n=5) and 28% in moderately cachectic mice (94 ± 5 mg; n=3) compared to mild/non-cachectic mice (134 ± 7 mg; n=4). Severely cachectic ApcMin/+ mice (3.05 ± 0.23 IOD) and moderately cachectic mice (2.11 ± 0.36 IOD) demonstrated a 2 to 3-fold increase in Bax protein compared to mild/non-cachectic mice (1.00 ±0.15 IOD). CONCLUSION: The induction of apoptosis may be critical for extreme muscle loss in cachectic mice. This study was funded by the Colorectal Cancer COBRE Program from the National Institute of Health/USC" @default.
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- W2092242559 date "2007-05-01" @default.
- W2092242559 modified "2023-09-26" @default.
- W2092242559 title "Skeletal Muscle Apoptosis During Cancer Cachexia in the Apc−/+ Mouse" @default.
- W2092242559 doi "https://doi.org/10.1249/01.mss.0000273836.43623.af" @default.
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