Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092243048> ?p ?o ?g. }
- W2092243048 endingPage "421" @default.
- W2092243048 startingPage "410" @default.
- W2092243048 abstract "Rivaling or cooperating with other post-translational modifications, ubiquitination plays central roles in regulating numerous cellular processes. Not surprisingly, gain- or loss-of-function mutations in several components of the ubiquitin system are causally linked to human pathologies including cancer. The covalent attachment of ubiquitin to target proteins occurs in sequential steps and involves ubiquitin ligases (E3s) which are the most abundant enzymes of the ubiquitin system. Although often associated with proteasomal degradation, ubiquitination is also involved in regulatory events in a proteasome-independent manner. Moreover, ubiquitination is reversible and specific proteases, termed deubiquitinases (DUBs), remove ubiquitin from protein substrates. While we now appreciate the importance of ubiquitin signaling in coordinating a plethora of physio-pathological processes, the molecular mechanisms are not fully understood. This review summarizes current findings on the critical functions exerted by E3s and DUBs in transcriptional control, particularly chromatin remodeling and transcription initiation/elongation." @default.
- W2092243048 created "2016-06-24" @default.
- W2092243048 creator A5054944334 @default.
- W2092243048 creator A5055173079 @default.
- W2092243048 creator A5065879015 @default.
- W2092243048 date "2012-02-01" @default.
- W2092243048 modified "2023-10-01" @default.
- W2092243048 title "Roles of ubiquitin signaling in transcription regulation" @default.
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