FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092245588> ?p ?o ?g. }

• W2092245588 endingPage "26" @default.
• W2092245588 startingPage "14" @default.
• W2092245588 abstract "BCR/ABL expression is the key characteristic of chronic myeloid leukaemia (CML). The progression of CML is associated with genomic instability. Systematic analysis of DNA damage signalling in the presence of BCR/ABL thus offers opportunities to identify mechanisms of leukaemic progression. We therefore undertook a quantitative phosphoproteomics study to test whether BCR/ABL expression could globally affect the response to genotoxic stress signalling. Etoposide-induced DNA damage was chosen and the concentration and time of exposure determined such that apoptosis was not associated with the study. More than 1100 phosphoentities were identified. BCR/ABL was shown to significantly alter the response to etoposide in many cases. These include sites on MDC1, a key component of DNA repair, and Hemogen. Hemogen is a transcriptional target of HOXB4 and GATA1, two transcription factors involved in haemopoietic development, and is overexpressed in acute myeloid leukaemia. To validate Hemogen phosphorylation, absolute quantification using an isotopomeric standard and selected reaction monitoring was performed. This revealed a strong correlation with isobaric tagging data and offering quantification at about 10 fmol per million cells. Furthermore we found that multiple protein phosphorylation changes mediated by BCR/ABL were connected to the increased activation of NFκB, a key survival transcription factor, after etoposide exposure." @default.
• W2092245588 created "2016-06-24" @default.
• W2092245588 creator A5004375777 @default.
• W2092245588 creator A5027610062 @default.
• W2092245588 creator A5043906272 @default.
• W2092245588 creator A5076360005 @default.
• W2092245588 creator A5083606256 @default.
• W2092245588 creator A5085508344 @default.
• W2092245588 creator A5090337125 @default.
• W2092245588 date "2012-12-01" @default.
• W2092245588 modified "2023-09-26" @default.
• W2092245588 title "BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response" @default.
• W2092245588 cites W1965081118 @default.
• W2092245588 cites W1977843033 @default.
• W2092245588 cites W1984870370 @default.
• W2092245588 cites W1985775217 @default.
• W2092245588 cites W1991224394 @default.
• W2092245588 cites W1996243898 @default.
• W2092245588 cites W1999556153 @default.
• W2092245588 cites W2002297333 @default.
• W2092245588 cites W2007064610 @default.
• W2092245588 cites W2012610754 @default.
• W2092245588 cites W2015742390 @default.
• W2092245588 cites W2028222949 @default.
• W2092245588 cites W2033820733 @default.
• W2092245588 cites W2037951413 @default.
• W2092245588 cites W2040323503 @default.
• W2092245588 cites W2046916766 @default.
• W2092245588 cites W2047224624 @default.
• W2092245588 cites W2050860701 @default.
• W2092245588 cites W2065387190 @default.
• W2092245588 cites W2070728573 @default.
• W2092245588 cites W2072478240 @default.
• W2092245588 cites W2073559097 @default.
• W2092245588 cites W2074483662 @default.
• W2092245588 cites W2105142153 @default.
• W2092245588 cites W2105617035 @default.
• W2092245588 cites W2106225536 @default.
• W2092245588 cites W2107958288 @default.
• W2092245588 cites W2114907977 @default.
• W2092245588 cites W2120875343 @default.
• W2092245588 cites W2128989133 @default.
• W2092245588 cites W2134240260 @default.
• W2092245588 cites W2148365034 @default.
• W2092245588 cites W2148753835 @default.
• W2092245588 cites W2165848530 @default.
• W2092245588 cites W2324425957 @default.
• W2092245588 cites W2402402931 @default.
• W2092245588 cites W3113125785 @default.
• W2092245588 cites W3140430254 @default.
• W2092245588 doi "https://doi.org/10.1016/j.jprot.2012.06.003" @default.
• W2092245588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22705319" @default.
• W2092245588 hasPublicationYear "2012" @default.
• W2092245588 type Work @default.
• W2092245588 sameAs 2092245588 @default.
• W2092245588 citedByCount "9" @default.
• W2092245588 countsByYear W20922455882012 @default.
• W2092245588 countsByYear W20922455882013 @default.
• W2092245588 countsByYear W20922455882014 @default.
• W2092245588 countsByYear W20922455882015 @default.
• W2092245588 countsByYear W20922455882016 @default.
• W2092245588 countsByYear W20922455882018 @default.
• W2092245588 crossrefType "journal-article" @default.
• W2092245588 hasAuthorship W2092245588A5004375777 @default.
• W2092245588 hasAuthorship W2092245588A5027610062 @default.
• W2092245588 hasAuthorship W2092245588A5043906272 @default.
• W2092245588 hasAuthorship W2092245588A5076360005 @default.
• W2092245588 hasAuthorship W2092245588A5083606256 @default.
• W2092245588 hasAuthorship W2092245588A5085508344 @default.
• W2092245588 hasAuthorship W2092245588A5090337125 @default.
• W2092245588 hasBestOaLocation W20922455882 @default.
• W2092245588 hasConcept C104317684 @default.
• W2092245588 hasConcept C11960822 @default.
• W2092245588 hasConcept C143425029 @default.
• W2092245588 hasConcept C153911025 @default.
• W2092245588 hasConcept C2776694085 @default.
• W2092245588 hasConcept C2778119113 @default.
• W2092245588 hasConcept C2778729363 @default.
• W2092245588 hasConcept C43907098 @default.
• W2092245588 hasConcept C502942594 @default.
• W2092245588 hasConcept C54355233 @default.
• W2092245588 hasConcept C552990157 @default.
• W2092245588 hasConcept C86339819 @default.
• W2092245588 hasConcept C86803240 @default.
• W2092245588 hasConcept C95444343 @default.
• W2092245588 hasConceptScore W2092245588C104317684 @default.
• W2092245588 hasConceptScore W2092245588C11960822 @default.
• W2092245588 hasConceptScore W2092245588C143425029 @default.
• W2092245588 hasConceptScore W2092245588C153911025 @default.
• W2092245588 hasConceptScore W2092245588C2776694085 @default.
• W2092245588 hasConceptScore W2092245588C2778119113 @default.
• W2092245588 hasConceptScore W2092245588C2778729363 @default.
• W2092245588 hasConceptScore W2092245588C43907098 @default.
• W2092245588 hasConceptScore W2092245588C502942594 @default.
• W2092245588 hasConceptScore W2092245588C54355233 @default.
• W2092245588 hasConceptScore W2092245588C552990157 @default.
• W2092245588 hasConceptScore W2092245588C86339819 @default.
• W2092245588 hasConceptScore W2092245588C86803240 @default.

• next