FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092245909> ?p ?o ?g. }

• W2092245909 endingPage "800" @default.
• W2092245909 startingPage "793" @default.
• W2092245909 abstract "Background Changes in densities and in the morphology of dendritic spines in the hippocampus are linked to hippocampal long-term potentiation (LTP), spatial learning, and depression. Decreased brain-derived neurotrophic factor (BDNF) levels seem to contribute to depression. Through its receptor trkB, BDNF is also involved in hippocampal LTP and hippocampus-dependent learning. Conditionally gene-targeted mice in which the ablation of trkB is restricted to the forebrain and occurs only during postnatal development display impaired learning and LTP. Methods To examine whether there is a link among impaired hippocampal synaptic plasticity, altered spines, and trkB receptors, we performed a quantitative analysis of spine densities and spine length in the hippocampal area CA1 and the dentate gyrus in conditional mutant mice (trkBlox/loxCaMKII-CRE mice). TrkB protein and mRNA levels were assayed using Western blot and in situ hybridization analysis. Results Fifteen-week-old mutant mice exhibit specific reductions in spine densities and a significant increase in spine length of apical and basal dendrites in area CA1. These alterations correlate with a time- and region-specific reduction in full-length trkB mRNA in the hippocampus. Conclusions TrkB functions in structural remodeling of hippocampal dendritic spines, which in turn may affect synaptic transmission and plasticity. Changes in densities and in the morphology of dendritic spines in the hippocampus are linked to hippocampal long-term potentiation (LTP), spatial learning, and depression. Decreased brain-derived neurotrophic factor (BDNF) levels seem to contribute to depression. Through its receptor trkB, BDNF is also involved in hippocampal LTP and hippocampus-dependent learning. Conditionally gene-targeted mice in which the ablation of trkB is restricted to the forebrain and occurs only during postnatal development display impaired learning and LTP. To examine whether there is a link among impaired hippocampal synaptic plasticity, altered spines, and trkB receptors, we performed a quantitative analysis of spine densities and spine length in the hippocampal area CA1 and the dentate gyrus in conditional mutant mice (trkBlox/loxCaMKII-CRE mice). TrkB protein and mRNA levels were assayed using Western blot and in situ hybridization analysis. Fifteen-week-old mutant mice exhibit specific reductions in spine densities and a significant increase in spine length of apical and basal dendrites in area CA1. These alterations correlate with a time- and region-specific reduction in full-length trkB mRNA in the hippocampus. TrkB functions in structural remodeling of hippocampal dendritic spines, which in turn may affect synaptic transmission and plasticity." @default.
• W2092245909 created "2016-06-24" @default.
• W2092245909 creator A5000986874 @default.
• W2092245909 creator A5030918821 @default.
• W2092245909 creator A5047686228 @default.
• W2092245909 creator A5048108627 @default.
• W2092245909 creator A5062997829 @default.
• W2092245909 creator A5065615846 @default.
• W2092245909 date "2006-05-01" @default.
• W2092245909 modified "2023-09-26" @default.
• W2092245909 title "Regional- and Age-Dependent Reduction in trkB Receptor Expression in the Hippocampus Is Associated with Altered Spine Morphologies" @default.
• W2092245909 cites W111926909 @default.
• W2092245909 cites W1521766330 @default.
• W2092245909 cites W1572640432 @default.
• W2092245909 cites W1642243794 @default.
• W2092245909 cites W1647836033 @default.
• W2092245909 cites W1798313689 @default.
• W2092245909 cites W1928374558 @default.
• W2092245909 cites W1963940970 @default.
• W2092245909 cites W1971263143 @default.
• W2092245909 cites W1980719669 @default.
• W2092245909 cites W1983080743 @default.
• W2092245909 cites W1989700831 @default.
• W2092245909 cites W1989838035 @default.
• W2092245909 cites W1990421253 @default.
• W2092245909 cites W1993294129 @default.
• W2092245909 cites W1998362560 @default.
• W2092245909 cites W2002928035 @default.
• W2092245909 cites W2011965698 @default.
• W2092245909 cites W2014643424 @default.
• W2092245909 cites W2019522971 @default.
• W2092245909 cites W2024929318 @default.
• W2092245909 cites W2025353122 @default.
• W2092245909 cites W2026624452 @default.
• W2092245909 cites W2050389368 @default.
• W2092245909 cites W2069312841 @default.
• W2092245909 cites W2071463202 @default.
• W2092245909 cites W2074698464 @default.
• W2092245909 cites W2078035790 @default.
• W2092245909 cites W2078529082 @default.
• W2092245909 cites W2089161864 @default.
• W2092245909 cites W2090116050 @default.
• W2092245909 cites W2091363587 @default.
• W2092245909 cites W2096448639 @default.
• W2092245909 cites W2096610613 @default.
• W2092245909 cites W2110795584 @default.
• W2092245909 cites W2111843739 @default.
• W2092245909 cites W2124683806 @default.
• W2092245909 cites W2124788502 @default.
• W2092245909 cites W2134878072 @default.
• W2092245909 cites W2136761139 @default.
• W2092245909 cites W2138910339 @default.
• W2092245909 cites W2145643383 @default.
• W2092245909 cites W2146286641 @default.
• W2092245909 cites W2152844559 @default.
• W2092245909 cites W2153504955 @default.
• W2092245909 cites W2232208156 @default.
• W2092245909 cites W4255247066 @default.
• W2092245909 cites W4300799228 @default.
• W2092245909 doi "https://doi.org/10.1016/j.biopsych.2005.08.025" @default.
• W2092245909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16325153" @default.
• W2092245909 hasPublicationYear "2006" @default.
• W2092245909 type Work @default.
• W2092245909 sameAs 2092245909 @default.
• W2092245909 citedByCount "55" @default.
• W2092245909 countsByYear W20922459092012 @default.
• W2092245909 countsByYear W20922459092013 @default.
• W2092245909 countsByYear W20922459092014 @default.
• W2092245909 countsByYear W20922459092015 @default.
• W2092245909 countsByYear W20922459092016 @default.
• W2092245909 countsByYear W20922459092017 @default.
• W2092245909 countsByYear W20922459092018 @default.
• W2092245909 countsByYear W20922459092019 @default.
• W2092245909 countsByYear W20922459092020 @default.
• W2092245909 countsByYear W20922459092021 @default.
• W2092245909 countsByYear W20922459092022 @default.
• W2092245909 countsByYear W20922459092023 @default.
• W2092245909 crossrefType "journal-article" @default.
• W2092245909 hasAuthorship W2092245909A5000986874 @default.
• W2092245909 hasAuthorship W2092245909A5030918821 @default.
• W2092245909 hasAuthorship W2092245909A5047686228 @default.
• W2092245909 hasAuthorship W2092245909A5048108627 @default.
• W2092245909 hasAuthorship W2092245909A5062997829 @default.
• W2092245909 hasAuthorship W2092245909A5065615846 @default.
• W2092245909 hasConcept C126322002 @default.
• W2092245909 hasConcept C148762608 @default.
• W2092245909 hasConcept C160539049 @default.
• W2092245909 hasConcept C169760540 @default.
• W2092245909 hasConcept C170493617 @default.
• W2092245909 hasConcept C174884520 @default.
• W2092245909 hasConcept C25274449 @default.
• W2092245909 hasConcept C2776464000 @default.
• W2092245909 hasConcept C2778790584 @default.
• W2092245909 hasConcept C2781161787 @default.
• W2092245909 hasConcept C71924100 @default.
• W2092245909 hasConcept C86803240 @default.
• W2092245909 hasConcept C97124661 @default.
• W2092245909 hasConcept C98229152 @default.

• next