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• W2092247835 abstract "Gamma inferferon (γIFN), alpha tumor necrosis factor (αTNF), and interleukin 6 (IL-60) are cytomines produced by a wide variety of cells, incuding T lymphocys and NK cells. These cytokines affect B-cell proliferation and differentiation into immunoglobulin seceting cells. In addition, γIFN and αTNF also enhance the function of macrophagesm, upregulating the expresson of their igG receptors. Abonormalities in the production of these cytokines may be involved in the clinical course of autoimmune thrombocytopenic purpura (ATP). This paper describes the production of these cytokines in PHA-stimulated peripheral blood CCD2+ cells from ATP patients. Both γIFN and αTNF were significantly increased in PHA-stimulated CD2+ cells from therapy-dependent ATP patients (platelet counts <50,000/μl), as compared to ATP patients with stable disease (sustained platelet counts >50,000/μl without need treatment) (P < 0.05). No significant differences were found in γlFN production by PHA-stimulated CD2+ cells between therapy-dependent ATP patients and healthy controls (P < 0.05). However, the production of αTNF by PHA-stimulated CD2+ cells from therapy-dependent ATP patients was significantly higher compared to that found in healthy controls (P < 0.05). There were no significant differences in IL-6 production by PHA-stimulated CD2+ cells from ATP patients and healthy controls (P < 0.05). These findings demonstrate abnormal γlFN and αTNF secretion in purified CD2 cells from ATP patients. The clinical severity of the disease is associated with the altered secretion of these lymphokines by CD2 cells. © 1995 Wiley-Liss, Inc." @default.
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• W2092247835 date "1995-08-01" @default.
• W2092247835 modified "2023-10-16" @default.
• W2092247835 title "Abnormal γIFN and αTNF secretion in purified CD2+ cells from autoimmune thrombocytopenic purpura (ATP) patients: Their implication in the clinical course of the disease" @default.
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• W2092247835 doi "https://doi.org/10.1002/ajh.2830490403" @default.
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