FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092247882> ?p ?o ?g. }

• W2092247882 endingPage "337" @default.
• W2092247882 startingPage "329" @default.
• W2092247882 abstract "In this work metabolic engineering strategies for maximizing l-(–)-carnitine production by Escherichia coli based on the Biochemical System Theory (1–3) and the Indirect Optimization Method are presented (4). The model integrates the metabolic and the bioreactor levels using power-law formalism. Based on the S-system model, the Indirect Optimization Method was applied, leading to profiles of parameter values that are compatible with both the physiology of the cells and the bioreactor system operating conditions. This guarantees their viability and fitness and yields higher rates of l-(–)-carnitine production. Experimental results using a high cell density reactor were compared with optimized predictions from the Indirect Optimization Method. When two parameters (the dilution rate and the initial crotonobetaine concentration) were directly changed in the real experimental system to the prescribed optimum values, the system showed better performance in l-(–)-carnitine production (74% increase in production rate), in close agreement with the modelapos;s predictions. The model shows control points at macroscopic (reactor operation) and microscopic (molecular) levels where conversion and productivity can be increased. In accordance with the optimized solution, the next logical step to improve the l-(–)-carnitine production rate will involve metabolic engineering of the E. coli strain by overexpressing the carnitine transferase, CaiB, activity and the protein carrier, CaiT, responsible for substrate and product transport in and out of the cell. By this means it is predicted production may be enhanced by up to three times the original value." @default.
• W2092247882 created "2016-06-24" @default.
• W2092247882 creator A5049000541 @default.
• W2092247882 creator A5055280080 @default.
• W2092247882 creator A5067743298 @default.
• W2092247882 creator A5070879539 @default.
• W2092247882 creator A5080540849 @default.
• W2092247882 creator A5091633756 @default.
• W2092247882 date "2008-09-05" @default.
• W2092247882 modified "2023-09-26" @default.
• W2092247882 title "Design of Metabolic Engineering Strategies for Maximizing l-(-)-Carnitine Production by Escherichia coli. Integration of the Metabolic and Bioreactor Levels" @default.
• W2092247882 cites W1497020935 @default.
• W2092247882 cites W1502529406 @default.
• W2092247882 cites W1535241806 @default.
• W2092247882 cites W1581582023 @default.
• W2092247882 cites W181452442 @default.
• W2092247882 cites W1965351176 @default.
• W2092247882 cites W1983975928 @default.
• W2092247882 cites W1985085839 @default.
• W2092247882 cites W2003440351 @default.
• W2092247882 cites W2015413380 @default.
• W2092247882 cites W2020419173 @default.
• W2092247882 cites W2034802234 @default.
• W2092247882 cites W2035841134 @default.
• W2092247882 cites W2050272518 @default.
• W2092247882 cites W2053628887 @default.
• W2092247882 cites W2058365734 @default.
• W2092247882 cites W2059220175 @default.
• W2092247882 cites W2061030220 @default.
• W2092247882 cites W2071478731 @default.
• W2092247882 cites W2072037281 @default.
• W2092247882 cites W2079400503 @default.
• W2092247882 cites W2089500357 @default.
• W2092247882 cites W2091250743 @default.
• W2092247882 cites W2117270379 @default.
• W2092247882 cites W2120954467 @default.
• W2092247882 cites W2161755044 @default.
• W2092247882 doi "https://doi.org/10.1021/bp0497583" @default.
• W2092247882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15801767" @default.
• W2092247882 hasPublicationYear "2008" @default.
• W2092247882 type Work @default.
• W2092247882 sameAs 2092247882 @default.
• W2092247882 citedByCount "16" @default.
• W2092247882 countsByYear W20922478822012 @default.
• W2092247882 countsByYear W20922478822013 @default.
• W2092247882 countsByYear W20922478822016 @default.
• W2092247882 countsByYear W20922478822020 @default.
• W2092247882 countsByYear W20922478822021 @default.
• W2092247882 crossrefType "journal-article" @default.
• W2092247882 hasAuthorship W2092247882A5049000541 @default.
• W2092247882 hasAuthorship W2092247882A5055280080 @default.
• W2092247882 hasAuthorship W2092247882A5067743298 @default.
• W2092247882 hasAuthorship W2092247882A5070879539 @default.
• W2092247882 hasAuthorship W2092247882A5080540849 @default.
• W2092247882 hasAuthorship W2092247882A5091633756 @default.
• W2092247882 hasConcept C104317684 @default.
• W2092247882 hasConcept C121332964 @default.
• W2092247882 hasConcept C127413603 @default.
• W2092247882 hasConcept C168170006 @default.
• W2092247882 hasConcept C178790620 @default.
• W2092247882 hasConcept C181199279 @default.
• W2092247882 hasConcept C183696295 @default.
• W2092247882 hasConcept C185592680 @default.
• W2092247882 hasConcept C186060115 @default.
• W2092247882 hasConcept C21880701 @default.
• W2092247882 hasConcept C2778435403 @default.
• W2092247882 hasConcept C41008148 @default.
• W2092247882 hasConcept C42360764 @default.
• W2092247882 hasConcept C547475151 @default.
• W2092247882 hasConcept C55493867 @default.
• W2092247882 hasConcept C6350086 @default.
• W2092247882 hasConcept C86803240 @default.
• W2092247882 hasConcept C96618451 @default.
• W2092247882 hasConcept C97355855 @default.
• W2092247882 hasConceptScore W2092247882C104317684 @default.
• W2092247882 hasConceptScore W2092247882C121332964 @default.
• W2092247882 hasConceptScore W2092247882C127413603 @default.
• W2092247882 hasConceptScore W2092247882C168170006 @default.
• W2092247882 hasConceptScore W2092247882C178790620 @default.
• W2092247882 hasConceptScore W2092247882C181199279 @default.
• W2092247882 hasConceptScore W2092247882C183696295 @default.
• W2092247882 hasConceptScore W2092247882C185592680 @default.
• W2092247882 hasConceptScore W2092247882C186060115 @default.
• W2092247882 hasConceptScore W2092247882C21880701 @default.
• W2092247882 hasConceptScore W2092247882C2778435403 @default.
• W2092247882 hasConceptScore W2092247882C41008148 @default.
• W2092247882 hasConceptScore W2092247882C42360764 @default.
• W2092247882 hasConceptScore W2092247882C547475151 @default.
• W2092247882 hasConceptScore W2092247882C55493867 @default.
• W2092247882 hasConceptScore W2092247882C6350086 @default.
• W2092247882 hasConceptScore W2092247882C86803240 @default.
• W2092247882 hasConceptScore W2092247882C96618451 @default.
• W2092247882 hasConceptScore W2092247882C97355855 @default.
• W2092247882 hasIssue "2" @default.
• W2092247882 hasLocation W20922478821 @default.
• W2092247882 hasLocation W20922478822 @default.
• W2092247882 hasOpenAccess W2092247882 @default.
• W2092247882 hasPrimaryLocation W20922478821 @default.

• next